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Last Updated: September 24, 2020

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Patent: 7,569,362

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Summary for Patent: 7,569,362
Title:Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing
Abstract: The invention provides a method of producing multiple polypeptides, such as antibodies or antibody fragments, in a eukaryotic cell using a single expression vector. The expression vector is engineered to comprise two or more expression cassettes under the control of a single promoter wherein the expression cassettes have splice sites which allow for their alternative splicing and expression as two or more independent gene products at a desired ratio. Use of the vector for the efficient expression of recombinant antibodies in eukaryotic host cells is disclosed as well as the use of such antibodies in diagnostic and therapeutic applications.
Inventor(s): Prentice; Holly (Carlisle, MA)
Assignee: Biogen Idec MA Inc. (Cambridge, MA)
Application Number:11/079,933
Patent Claims:see list of patent claims

Details for Patent 7,569,362

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Biogen Idec MA Inc. (Cambridge, MA) 2024-03-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Biogen Idec MA Inc. (Cambridge, MA) 2024-03-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Biogen Idec MA Inc. (Cambridge, MA) 2024-03-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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