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Last Updated: April 25, 2024

Patent: 7,547,435

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Summary for Patent: 7,547,435

Title:	Pharmacological vitreolysis
Abstract:	Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
Inventor(s):	Pakola; Steve (Sleepy Hollow, NY), De Smet; Marc (Amstelveen, NL)
Assignee:	ThromboGenics NV (Leuven, BE)
Application Number:	10/729,475
Patent Claims:	see list of patent claims

Details for Patent 7,547,435

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Thrombogenics Inc.	JETREA	ocriplasmin	Injection	125422	02/22/2017	⤷ Try a Trial	2022-12-06
Thrombogenics Inc.	JETREA	ocriplasmin	Injection	125422	10/17/2012	⤷ Try a Trial	2022-12-06
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,547,435

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Country	Patent Number	Estimated Expiration
Austria	534400	⤷ Try a Trial
Australia	2003300821	⤷ Try a Trial
Belgium	2013C055	⤷ Try a Trial
Brazil	0317033	⤷ Try a Trial
Brazil	PI0310144	⤷ Try a Trial
Canada	2508606	⤷ Try a Trial
China	100577202	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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