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Last Updated: July 5, 2020

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Patent: 7,378,426

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Summary for Patent: 7,378,426
Title:Fused heterotricyclic compounds as inhibitors of 17.beta.-hydroxysteroid dehydrogenase 3
Abstract: Disclosed are fused heterotricyclic compounds of the following formula I, ##STR00001## or an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof, wherein one of A ring or C ring is a 5-7 membered unsaturated heterocyclic ring. The disclosed compounds are useful as inhibitors of 17.beta.-hydroxysteroid dehydrogenase 3 (17.beta.-HSD3). Also disclosed are methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions comprising such compounds.
Inventor(s): Gavai; Ashvinikumar V. (Princeton Junction, NJ), Norris; Derek J. (Pennington, NJ), Han; Wen-Ching (Newtown, PA), Vite; Gregory D. (Titusville, NJ), Fink; Brian E. (West Windsor, NJ), Tokarski; John S. (Princeton, NJ)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:11/066,407
Patent Claims:see list of patent claims

Details for Patent 7,378,426

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2024-03-01 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2024-03-01 RX Orphan search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2024-03-01 RX Orphan search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2024-03-01 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2024-03-01 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2024-03-01 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 7,378,426

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