You are 3 steps away
from making better decisions

Serving leading biopharmaceutical companies globally:

Baxter
Harvard Business School
AstraZeneca
Colorcon
Merck
Boehringer Ingelheim

Last Updated: September 18, 2020

DrugPatentWatch Database Preview

Patent: 6,765,003

➤ Get the DrugPatentWatch Daily Briefing
» See Plans and Pricing

« Back to Dashboard

Summary for Patent: 6,765,003
Title: 3-Arylsulfonyl-2 (substituted methyl) propanoic acid derivatives as matrix metalloproteinase inhibitors
Abstract:Compounds which are 3-arylsulfonyl-2-methyl propanoic acid derivatives of formula (I): wherein X is HO--NH-- or HO--, R1 is selected from phenyl, 4-chlorophenyl, 4-florophenyl, 4-cyanophenyl, benzamido (i.e., --NH--CO-Ph) and benzamido substituted on the terminal phenyl ring by C.sub.1 -C.sub.4 alkyl, fluoro, chloro, cyano or C.sub.1-4 alkoxy; R.sub.2 is selected from (a) --S--Ar or --S--CH.sub.2 --Ar wherein Ar is an aromatic moiety; (b) --O--Ar wherein Ar is as defined above; (c) --S-Het or --S--CH.sub.2 -Het wherein Het is a heterocyclic ring; and (d) 2,5-dioxo-1-imidazolidinyl or 2,4-dioxo-1-imidazolinyl; and the pharmaceutically acceptable salts thereof; have potent and selective inhibitory activity against matrix metalloproteinases (MMPs) and can thus be used in the treatment and prevention of diseases mediated by MMPs.
Inventor(s): Mantegani; Sergio (Milan, IT), Abrate; Francesca (Milan, IT), Bissolino; Pierluigi (Pavia, IT), Cremonesi; Paolo (Milan, IT), Perrone; Ettore (Milan, IT), Jabes; Daniela (Milan, IT)
Assignee: Pharmacia Italia, SpA (Milan, IT)
Application Number:10/030,681
Patent Claims:see list of patent claims

Details for Patent 6,765,003

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Pharmacia Italia, SpA (Milan, IT) 2019-07-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

McKinsey
Medtronic
Merck
Dow
Johnson and Johnson
Harvard Business School

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.