Patent: 6,702,850

Summary for Patent: 6,702,850

Title:	Multi-coated drug-eluting stent for antithrombosis and antirestenosis
Abstract:	A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is comprised of a hydrophobic heparinized polymer that inhibits blood coagulation and provides a hydrophilic surface for reducing the friction between stent and lesion site. In preferred embodiments of the invention, the multi-layered stent is effective in deterring restenosis and thrombosis at the implant site. In these same preferred embodiments, the multi-layered stent is capable of reducing the burst release of the biologically active agents from the first layer and sustaining a release of an effective amount of these agents for a relatively extended period of time. Methods of applying the multi-layered coating to the stent surface are also part of this invention.
Inventor(s):	Byun; Youngro (Seoul, KR), Yoon; Jung Han (Seoul, KR)
Assignee:	Mediplex Corporation Korea (Seoul, KR)
Application Number:	10/262,432
Patent Claims:	see list of patent claims

Details for Patent 6,702,850

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2039-02-26
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989		2039-02-26
Clinigen, Inc.	PROLEUKIN	aldesleukin	For Injection	103293	05/05/1992		2039-02-26
Amgen, Inc.	NEUPOGEN	filgrastim	Injection	103353	02/20/1991		2039-02-26
Amgen, Inc.	NEUPOGEN	filgrastim	Injection	103353	06/28/2000		2039-02-26
Partner Therapeutics, Inc.	LEUKINE	sargramostim	For Injection	103362	03/05/1991		2039-02-26
Partner Therapeutics, Inc.	LEUKINE	sargramostim	Injection	103362	03/05/1991		2039-02-26