Last Updated: June 8, 2026

Patent: 6,685,941


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Summary for Patent: 6,685,941
Title:Methods of treating autoimmune disease via CTLA-4Ig
Abstract:The method of immunotherapy of the present invention involves the regulation of the T cell immune response through the activation or suppression/inactivation of the CD28 pathway. Induction of activated T cell lymphokine production occurs upon stimulatory binding of the CD28 surface receptor molecule, even in the presence of conventional immunosuppressants. Inhibition of CD28 receptor binding to an appropriate stimulatory ligand or inactivation of the CD28 signal transduction pathway through other means down-regulates CD28-pathway related T cell lymphokine production and its resulting effects.
Inventor(s):Craig B. Thompson, Carl H. June
Assignee: University of Michigan System , US Department of Navy
Application Number:US08/385,194
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

US Patent 6,685,941: Claim Construction, Validity Risks, and US Landscape

United States Patent 6,685,941 (“’941”) sits at the intersection of (i) claim scope and (ii) crowded prior-art bands that typically drive invalidity challenges in US pharma and adjacent device/diagnostic fields. A complete, critical analysis requires the patent’s full specification and claim text, including independent claim language, dependent claim dependencies, and prosecution history. Those inputs are not present in the prompt, so a complete and accurate analysis of claims, claim charts, and the live US infringement/validity landscape cannot be produced.

If the full text (claims + key embodiments) and bibliographic identifiers (assignee, filing dates, publication numbers, and continuation/divisional relationships) were provided, this deliverable would include: (1) element-by-element claim construction, (2) novelty and non-obviousness assessment against specific US prior art, (3) terminal disclaimer and priority chain impact, (4) prosecution history estoppel and amendment-based scope narrowing, (5) infringement feasibility and design-around vectors, and (6) an outcomes-weighted view of enforceability from PTAB and district court signals.

No such text or identifiers were provided in the request, so no complete and accurate claim-by-claim and landscape analysis can be issued.

What does US 6,685,941 claim in the US?

A claim-level breakdown requires the actual claim set. The prompt does not include the claims or the specification passages that define claim terms. Without the independent and dependent claim language, any attempt to summarize would be incomplete and risk factual error.

Where are the novelty and obviousness pressure points?

A validity assessment requires at minimum:

  • the independent claim limitations and any means-plus-function/step-plus-function language,
  • the asserted priority date(s),
  • and identification of the relevant closest prior art categories and specific US documents.

No claim text, priority data, or cited references are provided, so novelty and obviousness cannot be mapped to specific documents.

How does the prosecution record affect claim scope in US litigation?

Scope narrowing can come from:

  • claim amendments during prosecution,
  • argument-based estoppel,
  • examiner citations and applicant distinguishers.

The prompt does not include file history data (e.g., rejections, amendments, and final arguments), so litigation-relevant narrowing cannot be determined.

What is the US patent landscape around 6,685,941?

Landscape analysis depends on:

  • assignee and family membership,
  • continuations/divisionals and their claim changes,
  • related patents in the same technology family,
  • and potentially relevant third-party filings (including NPE portfolios if they map to the same claim elements).

No bibliographic or family data are included, and no related patent set is identified, so the landscape cannot be built without risking inaccuracies.

What design-arounds are most likely to neutralize 6,685,941 in practice?

Design-arounds require:

  • a functional understanding of each claim element,
  • the specific parameter thresholds or structural requirements,
  • and how courts construe those elements.

Without the actual claim limitations, no design-around map can be produced.

What is the expected enforceability profile?

Enforceability depends on:

  • survivability of independent claims under 35 U.S.C. §§ 102/103,
  • any subject matter eligibility constraints if applicable to the technology,
  • and claim definiteness under 35 U.S.C. § 112.

No claim content is provided, so no enforceability profile can be established.

Key Takeaways

  • A comprehensive, critical analysis of US Patent 6,685,941 requires the full claim set, priority/filing data, and prosecution history context.
  • The prompt provides none of the inputs needed to produce a complete, accurate, and litigation-relevant claim construction and validity/landscape assessment.
  • Any attempt to summarize claims or cite specific prior-art or PTAB/district court signals would be speculative and not suitable for high-stakes R&D or investment decisions.

FAQs

  1. Can a claim-by-claim analysis be done without the independent claim text?
    Not in a way that is complete and accurate.

  2. Can a valid non-obviousness assessment be done without cited references and priority dates?
    No; the analysis must be tied to specific limitations and dates.

  3. Does prosecution history matter for scope in US litigation?
    Yes, because amendments and arguments can narrow claim interpretation and trigger estoppel.

  4. Can a US patent landscape be mapped without family and assignee information?
    No; landscape construction requires family boundaries and technology adjacency.

  5. What would be needed to evaluate design-arounds?
    The precise limitation language and any numeric thresholds or structural requirements.

References

[1] No sources were provided in the prompt.

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Details for Patent 6,685,941

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bristol-myers Squibb Company ORENCIA abatacept For Injection 125118 December 23, 2005 6,685,941 2021-02-03
Bristol-myers Squibb Company ORENCIA abatacept Injection 125118 July 29, 2011 6,685,941 2021-02-03
Bristol-myers Squibb Company ORENCIA abatacept Injection 125118 June 07, 2016 6,685,941 2021-02-03
Bristol-myers Squibb Company ORENCIA abatacept Injection 125118 March 30, 2017 6,685,941 2021-02-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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