Claims for Patent: 6,685,941

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Summary for Patent: 6,685,941

Title:	Methods of treating autoimmune disease via CTLA-4Ig
Abstract:	The method of immunotherapy of the present invention involves the regulation of the T cell immune response through the activation or suppression/inactivation of the CD28 pathway. Induction of activated T cell lymphokine production occurs upon stimulatory binding of the CD28 surface receptor molecule, even in the presence of conventional immunosuppressants. Inhibition of CD28 receptor binding to an appropriate stimulatory ligand or inactivation of the CD28 signal transduction pathway through other means down-regulates CD28-pathway related T cell lymphokine production and its resulting effects.
Inventor(s):	Craig B. Thompson, Carl H. June
Assignee:	University of Michigan System , US Department of Navy
Application Number:	US08/385,194

Details for Patent 6,685,941

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bristol-myers Squibb Company	ORENCIA	abatacept	For Injection	125118	December 23, 2005	6,685,941	2021-02-03
Bristol-myers Squibb Company	ORENCIA	abatacept	Injection	125118	July 29, 2011	6,685,941	2021-02-03
Bristol-myers Squibb Company	ORENCIA	abatacept	Injection	125118	June 07, 2016	6,685,941	2021-02-03
Bristol-myers Squibb Company	ORENCIA	abatacept	Injection	125118	March 30, 2017	6,685,941	2021-02-03
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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