Last Updated: November 8, 2026

Patent: 6,599,724

Summary for Patent: 6,599,724

Title:	Stable factor VIII compositions
Abstract:	The present invention relates to a pharmaceutical composition comprising Factor VIII and the divalent metal ions Zn2+ and Cu2+, optionally in the presence of Ca2+ ions and/or Mn2+ ions, wherein said Factor VIII is stable without the addition of albumin. The invention also relates to a method for the production of recombinant Factor VIII from mammalian cells carrying the gene therefor, comprising culturing said mammalian cells in medium free of plasma-derived protein and supplemented with divalent metal ions, including Cu2+ and Zn2+, and optionally in the presence of Ca2+ and Mn2+ ions.
Inventor(s):	Marianne Mikaelsson, Helena Sandberg
Assignee:	Swedish Orphan Biovitrum AB
Application Number:	US09/615,001
Patent Claims:	see list of patent claims

Details for Patent 6,599,724

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Llc	REFACTO	antihemophilic factor (recombinant)	For Injection	103779	June 27, 2001	6,599,724	2020-07-12
Wyeth Pharmaceuticals Llc	REFACTO	antihemophilic factor (recombinant)	For Injection	103779	July 6, 2001	6,599,724	2020-07-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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