Patent: 6,544,527
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Summary for Patent: 6,544,527
| Title: | Non-infectious, immunogenic, human immunodeficiency virus-like particles devoid of long terminal repeats and a functional pol coding region |
| Abstract: | Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product, eliminate integrase activity of the pol gene product and eliminate RNase H activity of the pol gene product through genetic manipulation of the gag and pol genes. The corresponding nucleic acid molecules are described. The non-infectious, retrovirus-like particles have utility in in vivo administration including to humans and in diagnosis. |
| Inventor(s): | Benjamin Rovinski, Shi-Xian Cao, Fei-Long Yao, Roy Persson, Michel H. Klein |
| Assignee: | Sanofi Pasteur Ltd |
| Application Number: | US08/680,525 |
| Patent Claims: | see list of patent claims |
Details for Patent 6,544,527
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Glaxosmithkline Biologicals | TWINRIX | hepatitis a & hepatitis b (recombinant) vaccine | Injection | 103850 | 11-May-01 | 6,544,527 | 2016-07-09 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
