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Generated: September 16, 2019

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Patent: 6,462,041

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Summary for Patent: 6,462,041
Title: Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis
Abstract:The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by the general Formulae I-III: ##STR1## wherein R.sub.1 -R.sub.5 are defined herein. The present invention also relates to the discovery that compounds having Formula I-III are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled cell growth and spread of abnormal cells occurs.
Inventor(s): Cai; Sui Xiong (San Diego, CA), Zhang; Han-Zhong (San Diego, CA), Wang; Yan (San Diego, CA), Tseng; Ben (San Diego, CA), Kasibhatla; Shailaja (San Diego, CA), Drewe; John A. (Costa Mesa, CA)
Assignee: Cytovia, Inc. (San Diego, CA)
Application Number:09/495,120
Patent Claims:see list of patent claims

Details for Patent 6,462,041

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Try a Free Trial Cytovia, Inc. (San Diego, CA) 2019-05-21 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Try a Free Trial Cytovia, Inc. (San Diego, CA) 2019-05-21 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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