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Last Updated: March 24, 2023

Patent: 6,346,274

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Summary for Patent: 6,346,274
Title: Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof
Abstract:The invention concerns parenteral pharmaceutical forms of administration containing polypeptide in the form of microparticles and a process for the production thereof. The microparticles according to the invention contain as a biodegradable polymer an ABA triblock copolymer the A block of which is a copolymer of lactic and glycolic acid and the B block of which represents a polyethylene glycol chain, together with additives that are selected from the group comprising serum proteins, polyamino acids, cyclodextrins, cyclodextrin derivatives, saccharides, amino sugars, amino acids, detergents or carboxylic acids as well as mixtures of these additives. The microparticles according to the invention continuously release the polypeptide over a relatively long time period even when the amounts of polypeptide they include are small or susceptible to aggregation.
Inventor(s): Koll; Hans (Weilheim, DE), Winter; Gerhard (Dossenheim, DE), Kissel; Thomas (Marburg, DE), Morlock; Michael (Viernheim, DE)
Assignee: Roche Diagnostics GmbH (Mannheim, DE)
Application Number:08/894,796
Patent Claims:see list of patent claims

Details for Patent 6,346,274

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2015-03-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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