Last Updated: May 26, 2026

Patent: 6,150,163

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Summary for Patent: 6,150,163

Title:	Chondrocyte media formulations and culture procedures
Abstract:	One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In particular, the defined medium is useful in culturing fibroblasts, especially chondrocytes. Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes and enhancing the synthesis of a cartilage specific matrix using tumor growth factor beta (TGF- beta ). Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes using the combination of TGF- beta and IGF.
Inventor(s):	John M. McPherson, Peter C. Yaeger, Marie E. Brown, James G. Hanlon, Francois Binette
Assignee:	Vericel Corp
Application Number:	US09/229,430
Patent Claims:	see list of patent claims

Details for Patent 6,150,163

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Vericel Corporation	MACI	autologous cultured chondrocytes on porcine collagen membrane	Cell Sheets	125603	December 13, 2016	6,150,163	2019-01-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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