Last Updated: September 27, 2026

Patent: 6,118,045

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Summary for Patent: 6,118,045

Title:	Lysosomal proteins produced in the milk of transgenic animals
Abstract:	The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
Inventor(s):	Arnold J. J. Reuser, Ans T. Van der Ploeg, Frank R. Pieper, Martin Ph. Verbeet
Assignee:	ERAMUS UNIVERSITEIT , Erasmus Universiteit Rotterdam , Universiteit Leiden , Erasmus University Medical Center , Genzyme Therapeutic Products LP
Application Number:	US08/700,760
Patent Claims:	see list of patent claims

Details for Patent 6,118,045

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genzyme Corporation	MYOZYME	alglucosidase alfa	For Injection	125141	28-Apr-06	⤷ Start Trial	2016-07-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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