Last Updated: October 1, 2026

Patent: 5,948,410

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Summary for Patent: 5,948,410

Title:	Influenza vaccine
Abstract:	The present invention is concerned with an Influenza surface antigen vaccine obtainable by production from Influenza Viruses propagated on animal cell culture and having a host cell DNA content equal to or less than 25 pg per dose. The present invention is also concerned with a method for the preparation of surface antigen proteins from Influenza Viruses propagated on an animal cell culture comprising the subsequent steps of:a. treatment of the whole virus containing fluid obtained from the cell culture with a DNA digesting enzyme, andb. adding a cationic detergent,followed by isolation of the surface antigen proteins.
Inventor(s):	Gustaar J. M. Van Scharrenburg, Rudi Brands
Assignee:	Duphar International Research BV
Application Number:	US09/055,321
Patent Claims:	see list of patent claims

Details for Patent 5,948,410

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Medimmune, Llc	FLUMIST, FLUMIST QUAD	influenza vaccine live, intranasal	Suspension	125020	17-Jun-03	5,948,410	2018-04-06
Medimmune, Llc	FLUMIST, FLUMIST QUAD	influenza vaccine live, intranasal	Suspension	125020	29-Feb-12	5,948,410	2018-04-06
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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