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Last Updated: November 29, 2021

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Patent: 5,869,254

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Summary for Patent: 5,869,254
Title: Alteration of sequence of a target molecule by ribozyme catalyzed trans-splicing
Abstract:Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that protein naturally produced from the target nucleic acid prior to splicing. The method includes contacting the target nucleic acid molecule with a catalytic nucleic acid molecule including the separate nucleic acid molecule. Such contacting is performed under conditions in which at least a portion of the separate nucleic acid molecule is spliced with at least a portion of the target nucleic acid molecule to form a chimeric nucleic acid molecule. In this method, the catalytic nucleic molecule is chosen so that it is not naturally associated with the separate nucleic acid molecule.
Inventor(s): Sullenger; Bruce A. (Westminster, CO), Cech; Thomas R. (Boulder, CO)
Assignee: University Research Corporation (Boulder, CO)
Application Number:08/786,753
Patent Claims:see list of patent claims

Details for Patent 5,869,254

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2013-11-12
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2013-11-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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