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Last Updated: May 30, 2020

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Patent: 5,766,582

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Summary for Patent: 5,766,582
Title: Stable, aqueous alfa interferon solution formulations
Abstract:Process for making stable aqueous solution formulations containing alfa-type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride as a tonicity agent, and m-cresol as an antimicrobial preservative and which maintain high chemical, physical and biological stability of the alfa interferon for an extended storage period of at least 24 months are disclosed.
Inventor(s): Yuen; Pui-Ho C. (Princeton Junction, NJ), Kline; Douglas F. (Hoboken, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:08/329,813
Patent Claims:see list of patent claims

Details for Patent 5,766,582

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Schering Corporation (Kenilworth, NJ) 2039-03-29 RX company
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Schering Corporation (Kenilworth, NJ) 2039-03-29 RX company
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Schering Corporation (Kenilworth, NJ) 2039-03-29 RX company
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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