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Last Updated: April 19, 2024

Patent: 5,935,566


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Summary for Patent: 5,935,566
Title: Stable aqueous alfa interferon solution formulations
Abstract:Stable aqueous solution formulations containing alfa-interferon type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride as a tonicity agent, and m-cresol as an antimicrobial preservative and which maintain high chemical, physical and biological stability of the alfa-type interferon for an extended storage period of at least 24 months are disclosed.
Inventor(s): Yuen; Pui-Ho C. (Princeton Junction, NJ), Kline; Douglas F. (Hoboken, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:09/096,708
Patent Claims:see list of patent claims

Details for Patent 5,935,566

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2014-10-11
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2014-10-11
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2014-10-11
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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