Last Updated: August 9, 2026

Patent: 5,935,566

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Summary for Patent: 5,935,566

Title:	Stable aqueous alfa interferon solution formulations
Abstract:	Stable aqueous solution formulations containing alfa-interferon type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride as a tonicity agent, and m-cresol as an antimicrobial preservative and which maintain high chemical, physical and biological stability of the alfa-type interferon for an extended storage period of at least 24 months are disclosed.
Inventor(s):	Yuen; Pui-Ho C. (Princeton Junction, NJ), Kline; Douglas F. (Hoboken, NJ)
Assignee:	Schering Corporation (Kenilworth, NJ)
Application Number:	09/096,708
Patent Claims:	see list of patent claims

Details for Patent 5,935,566

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Llc	INTRON A	interferon alfa-2b	For Injection	103132	June 04, 1986	5,935,566	2018-06-12
Merck Sharp & Dohme Llc	INTRON A	interferon alfa-2b	For Injection	103132		5,935,566	2018-06-12
Merck Sharp & Dohme Llc	INTRON A	interferon alfa-2b	Injection	103132		5,935,566	2018-06-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,935,566

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	9611018	⤷ Start Trial
United States of America	5766582	⤷ Start Trial
Ukraine	42028	⤷ Start Trial
Slovakia	282949	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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