Patent: 5,650,503

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Summary for Patent: 5,650,503

Title:	Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals
Abstract:	Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5\'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5\'-flanking sequence is sufficient to drive expression of the heterologous protein.
Inventor(s):	Archibald; Alan Langskill (Edinburgh, GB), Clark; Anthony John (Lasswade, GB), Harris; Stephen (Edinburgh, GB), McClenaghan; Margaret (Edinburgh, GB), Simons; Jonathan Paul (Edinburgh, GB), Whitelaw; Christopher Bruce Alexander (Edinburgh, GB)
Assignee:	PPL Therapeutics (Scotland) Limited (Edinburgh, GB6)
Application Number:	08/359,854
Patent Claims:	see list of patent claims

Details for Patent 5,650,503

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Sign Up	2008-11-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Sign Up	2008-11-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Sign Up	2008-11-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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