Patent: 5,567,677
✉ Email this page to a colleague
Summary for Patent: 5,567,677
| Title: | Protein formulation comprising growth hormone |
| Abstract: | The invention relates to injectable formulations of growth hormone comprising citrate as buffer substance. The formulation could be an aqueous solution of growth hormone and citrate as buffer substance in a concentration of 2-50 mM. The formulation of the growth hormone could comprise growth factor, amino acids such as e.g. glycine and alanine and/or mannitol or other sugar alcohols and/or glycerol and/or other carbohydrates and optionally a preservative such as benzyl alcohol. The invention also relates to a process for preparation of the formulation by mixing growth hormone with citrate as buffer substance or by adding the constituents of the final formulation on the last gel purification step. |
| Inventor(s): | Staffan Castensson, Ebba Florin-Robertsson, Elvy H okby, Sirkka Thom e |
| Assignee: | Pfizer Health AB |
| Application Number: | US08/162,017 |
| Patent Claims: | see list of patent claims |
Details for Patent 5,567,677
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Sandoz Inc. | OMNITROPE | somatropin | For Injection | 021426 | 30-May-06 | 5,567,677 | 2013-10-22 |
| Sandoz Inc. | OMNITROPE | somatropin | Injection | 021426 | 16-Jan-08 | 5,567,677 | 2013-10-22 |
| Sandoz Inc. | OMNITROPE | somatropin | Injection | 021426 | 25-Aug-08 | 5,567,677 | 2013-10-22 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
