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Last Updated: July 21, 2024

Patent: 5,549,892


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Summary for Patent: 5,549,892
Title: Enhanced in vivo uptake of glucocerebrosidase
Abstract:A pharmaceutical composition comprising remodelled recombinant glucocerebrosidase (GCR) is described that provides a therapeutic effect at doses that are lower then those required using remodelled naturally occurring GCR. A method of treating patients with Gaucher\'s disease using remodelled recombinant GCR is also provided. In vivo uptake of exogenous molecules can be determined by extracting a mixture of cells from a subject, enriching the target cells in vitro, lysing the cells and determining the amount of exogenous molecules.
Inventor(s): Friedman; BethAnn (Arlington, MA), Hayes; Michael (Acton, MA)
Assignee: Genzyme Corporation (Cambridge, MA)
Application Number:08/080,855
Patent Claims:see list of patent claims

Details for Patent 5,549,892

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation CEREZYME imiglucerase For Injection 020367 May 23, 1994 ⤷  Sign Up 2013-08-27
Genzyme Corporation CEREZYME imiglucerase For Injection 020367 September 22, 1999 ⤷  Sign Up 2013-08-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 5,549,892

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 9007573 ⤷  Sign Up
United States of America 6451600 ⤷  Sign Up
United States of America 5236838 ⤷  Sign Up
United States of America 2005026249 ⤷  Sign Up
United States of America 2005019861 ⤷  Sign Up
United States of America 2002168750 ⤷  Sign Up
>Country >Patent Number >Estimated Expiration

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