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Last Updated: October 22, 2021

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Patent: 5,491,075

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Summary for Patent: 5,491,075
Title: Cloning and expression of biologically active .alpha.-N-acetylgalactosaminidase
Abstract:The present invention involves the production of human .alpha.-GalNAc by cloning and expressing the .alpha.-GalNAc coding sequence in eukaryotic host cell expressions systems. The eukaryotic expression systems, and in particular the mammalian host cell expression systems described herein provide for the appropriate co-translational and post-translation modifications required or proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. The .alpha.-GalNAc produced in accordance with the invention may be used in the treatment of Schindler disease or for the hydrolysis of .alpha.-N-acetylgalactosaminyl moieties in various glycoconjugates.
Inventor(s): Desnick; Robert J. (New York, NY), Bishop; David F. (New York, NY), Ioannou; Yiannis A. (New York, NY), Wang; Anne M. (New York, NY)
Assignee: The Mount Sinai School of Medicine of the City University of New York (New York, NY)
Application Number:08/261,578
Patent Claims:see list of patent claims

Details for Patent 5,491,075

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Free Forever Trial 2013-02-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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