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Generated: September 15, 2019

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Patent: 5,491,075

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Summary for Patent: 5,491,075
Title: Cloning and expression of biologically active .alpha.-N-acetylgalactosaminidase
Abstract:The present invention involves the production of human .alpha.-GalNAc by cloning and expressing the .alpha.-GalNAc coding sequence in eukaryotic host cell expressions systems. The eukaryotic expression systems, and in particular the mammalian host cell expression systems described herein provide for the appropriate co-translational and post-translation modifications required or proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. The .alpha.-GalNAc produced in accordance with the invention may be used in the treatment of Schindler disease or for the hydrolysis of .alpha.-N-acetylgalactosaminyl moieties in various glycoconjugates.
Inventor(s): Desnick; Robert J. (New York, NY), Bishop; David F. (New York, NY), Ioannou; Yiannis A. (New York, NY), Wang; Anne M. (New York, NY)
Assignee: The Mount Sinai School of Medicine of the City University of New York (New York, NY)
Application Number:08/261,578
Patent Claims:see list of patent claims

Details for Patent 5,491,075

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up The Mount Sinai School of Medicine of the City University of New York (New York, NY) 2013-02-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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