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Last Updated: March 30, 2023

Patent: 5,420,242

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Summary for Patent: 5,420,242
Title: Production of human parathyroid hormone from microorganisms
Abstract:The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli, transformed by these plasmids. The invention also provides a plasmid for insertion into yeast and a transformed yeast in which the plasmid contains DNA coding for parathyroid hormone. Parathyroid hormone is then secreted by the transformed yeast. Further the invention provides alternate polypeptides having parathyroid hormone activity, including PTH analogs, fragments and extensions, and provides alternate leader sequences and secretion signal sequences which can be used in the present invention. Finally, there are provided methods for purification of the secreted PTH hormone and/or derivatives.
Inventor(s): Gautvik; Kaare M. (Oslo, NO), Alestrom; Peter (Sollihogda, NO), Oyen; Tordis B. (Oslo, NO)
Assignee: Gautvik; Kaare M. (both of, NO) Alestrom; Peter (both of, NO)
Application Number:08/087,471
Patent Claims:see list of patent claims

Details for Patent 5,420,242

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 ⤷  Sign Up 2009-08-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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