Patent: 4,806,346
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Summary for Patent: 4,806,346
| Title: | Method for isolation of antigen specific immunoglobulin |
| Abstract: | A process for preparing the purified F(ab).sub.2 fragment of equine Ig(T) from horses hyperimmunized with snake venom which comprises: (a) passing crude diluted hyperimmune equine serum contianing snake venom antigen specific Ig(T) buffered to an acidic pH through a strong base anion exchange polymer; (b) passing the resultant pass-through solution to which is added sodium chloride to a concentration of 0.05-0.124M through a strong acid cation exchange polymer; (c) adjusting the pH of the pass-through of step (b) to a pH of 3.3, and digesting said pass-through with pepsin; and (d) ultrafiltering said pepsin-digested pass-through to obtain purified F(ab).sub.2 fragment of the snake venom antigen specific equine Ig(T). |
| Inventor(s): | Hum; Wah-tung (Jeffersonville, PA), Lee; Shaw-guang (Villanova, PA) |
| Assignee: | American Home Products Corporation (New York, NY) |
| Application Number: | 06/942,313 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,806,346
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Merck Sharp & Dohme Corp. | LACTRODECTUS MACTANS | antivenin (latrodectus mactans) | For Injection | 101062 | 02/13/1936 | ⤷ Try a Trial | 2040-01-27 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
