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Last Updated: September 27, 2020

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Patent: 4,806,346

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Summary for Patent: 4,806,346
Title: Method for isolation of antigen specific immunoglobulin
Abstract:A process for preparing the purified F(ab).sub.2 fragment of equine Ig(T) from horses hyperimmunized with snake venom which comprises: (a) passing crude diluted hyperimmune equine serum contianing snake venom antigen specific Ig(T) buffered to an acidic pH through a strong base anion exchange polymer; (b) passing the resultant pass-through solution to which is added sodium chloride to a concentration of 0.05-0.124M through a strong acid cation exchange polymer; (c) adjusting the pH of the pass-through of step (b) to a pH of 3.3, and digesting said pass-through with pepsin; and (d) ultrafiltering said pepsin-digested pass-through to obtain purified F(ab).sub.2 fragment of the snake venom antigen specific equine Ig(T).
Inventor(s): Hum; Wah-tung (Jeffersonville, PA), Lee; Shaw-guang (Villanova, PA)
Assignee: American Home Products Corporation (New York, NY)
Application Number:06/942,313
Patent Claims:see list of patent claims

Details for Patent 4,806,346

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ANTIVENIN latrodectus mactans KIT 101062 1 2014-12-01   Start Trial American Home Products Corporation (New York, NY) 2040-01-27 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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