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Last Updated: July 30, 2021

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Patent: 4,798,786

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Summary for Patent: 4,798,786
Title: Living cells encapsulated in crosslinked protein
Abstract:Living cells are encapsulated by: (a) dispersing living cells in an aqueous solution of a capsule wall-forming protein; (b) forming aqueous droplets of the cell containing dispersion in an aqueous-immiscible, cell compatible continuous processing medium; and (c) crosslinking the protein with a crosslinking agent which is soluble in the continuous processing medium but substantially insoluble in the aqueous droplets. The resultant capsules containing living cells may be treated with a capsule wall degrading enzyme to enlarge pores of the capsules. The encapsulated cells may be used for administration of cells to an animal for growing the cells in the animal or for delivery to the animal of a substance produced by the cells. By the cells being encapsulated, the cells are not destroyed by the aminal immune system and immune response by the animal may be minimized.
Inventor(s): Tice; Thomas R. (Birmingham, AL), Meyers; William E. (Helena, AL)
Assignee: Stolle Research and Development Corporation (Cincinnati, OH)
Application Number:06/375,710
Patent Claims:see list of patent claims

Details for Patent 4,798,786

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Aimmune Therapeutics PALFORZIA peanut KIT 125696 1 2020-01-31 ⤷  Free Forever Trial Stolle Research and Development Corporation (Cincinnati, OH) 2039-03-29 search
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial Stolle Research and Development Corporation (Cincinnati, OH) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Baxter
McKesson
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Medtronic

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