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Last Updated: September 25, 2020

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Patent: 4,720,385

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Summary for Patent: 4,720,385
Title: Protein compositions substantially free from infectious agents
Abstract:Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein composition with a complex formed from transition metal ions, such as copper ions, and an angularly-fused, polynuclear heterocyclic arene having two nitrogen atoms in a \"cis-ortho\" relationship, such as phenanthroline, and a reducing agent such as a thiol or ascorbic acid or ascorbate salt or mixtures of ascorbic acid or ascorbate with a thiol in amounts and at a temperature and for a time sufficient to inactivate substantially all of the viruses and bacteria contained therein. Compositions containing therapeutically active proteins substantially free from viral and bacterial infectivity, which have heretofore been unattainable, can be prepared by the method of the invention.
Inventor(s): Lembach; Kenneth J. (Danville, CA)
Assignee: Miles Laboratories, Inc. (Elkhart, IN)
Application Number:06/736,197
Patent Claims:see list of patent claims

Details for Patent 4,720,385

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc PLASMANATE plasma protein fraction (human) SOLUTION 101140 1 1958-10-02   Start Trial Miles Laboratories, Inc. (Elkhart, IN) 2005-01-19 search
Baxalta Incorporated FEIBA anti-inhibitor coagulant complex KIT 101447 1 1986-01-31   Start Trial Miles Laboratories, Inc. (Elkhart, IN) 2005-01-19 search
Octapharma Usa Inc OCTAGAM IMMUNE GLOBULIN (HUMAN) immune globulin SOLUTION 125062 1 2004-05-21   Start Trial Miles Laboratories, Inc. (Elkhart, IN) 2005-01-19 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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