Last Updated: May 14, 2026

Patent: 4,704,273


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Summary for Patent: 4,704,273
Title: Methods and materials for treatment of rheumatoid arthritis
Abstract:Disclosed are methods and compositions useful for alleviating the symptoms of rheumatoid arthritis. In preferred embodiments, the compositions are administered in essentially minute \"neutralizing\" doses. The compositions comprise mixtures of histamine, immunoglobulin G provocative of RF formation or an immunologically active fraction thereof, collagen and either attenuated measles virus or immunologically active fraction thereof. Illustratively significant relief of symptoms of arthritis disease symptoms is achieved through parenteral (e.g., subcutaneous or sublingual) administration of such compositions.
Inventor(s): McMichael; John (Cambridge Springs, PA)
Application Number:06/833,998
Patent Claims:see list of patent claims

Details for Patent 4,704,273

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Csl Behring Ag CARIMUNE, CARIMUNE NF, PANGLOBULIN, SANDOGLOBULIN immune globulin intravenous (human) For Injection 102367 July 27, 2000 ⤷  Start Trial 2006-02-27
Alk-abello, Inc. HISTATROL positive skin test control-histamine Injection 103754 September 29, 1950 ⤷  Start Trial 2006-02-27
Jubilant Hollisterstier Llc N/A positive skin test control-histamine Injection 103891 March 13, 1924 ⤷  Start Trial 2006-02-27
Csl Behring Ag PRIVIGEN immune globulin intravenous (human), 10% liquid Injection 125201 July 26, 2007 ⤷  Start Trial 2006-02-27
Csl Behring Ag PRIVIGEN immune globulin intravenous (human), 10% liquid Injection 125201 October 02, 2009 ⤷  Start Trial 2006-02-27
Csl Behring Ag PRIVIGEN immune globulin intravenous (human), 10% liquid Injection 125201 February 07, 2013 ⤷  Start Trial 2006-02-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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