Patent: 4,540,792
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Summary for Patent: 4,540,792
| Title: | Process for the preparation of a free L .alpha.-amino acid |
| Abstract: | This invention relates to a process for the preparation of free L .alpha.-amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures. The process according to the present invention is characterized in that the D antipodes of an ester of said .alpha.-amino acid is racemized in the presence of a chemical catalyst formed by at least one aromatic aldehyde corresponding to the general formula: ##STR1## wherein: Ar represents an aromatic ring optionally containing a heteroatom, such as nitrogen, and B represents a basic function, to produce a mixture in dynamic equilibrium of the two forms D and L of said ester, the ester which is present in the L form is hydrolyzed enzymatically and irreversibly to produce the corresponding stereostable L .alpha.-amino acid, said stages of chemical racemization and of enzymatic hydrolysis being carried out under identical reaction conditions, and the free L .alpha.-amino acid is recovered. |
| Inventor(s): | Commeyras; Auguste (Clapiers, FR), Previero; Aldo (Montpellier, FR), Pugniere; Martine (Montpellier, FR) |
| Assignee: | Centre National de la Recherche Scientifique (Paris, FR) Institut National de la Sante et de la Reserche Medicale (Paris, FR) |
| Application Number: | 06/472,479 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,540,792
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 11/10/1982 | ⤷ Try a Trial | 2002-09-10 |
| Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 08/21/1984 | ⤷ Try a Trial | 2002-09-10 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
