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Last Updated: May 31, 2023

Patent: 4,447,355

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Summary for Patent: 4,447,355
Title: Method for stabilizing a tumor necrosis factor and a stable aqueous solution or powder containing the same
Abstract:A method for stabilizing a Tumor Necrosis Factor (TNF), which comprises adding at least one member selected from the group consisting of an albumin, a gelatin, a globulin, a protamine and a salt of protamine to an aqueous solution or powder containing TNF, and a stable aqueous solution or powder which contains TNF and an effective amount of such a protein. The aqueous solution or powder containing TNF can be stored for a prolonged period of time without losing its activity, and is stable on freezing, thawing, lyophilization or the like.
Inventor(s): Sakamoto; Hajimu (Fuji, JP), Kiyota; Takao (Fuji, JP), Hayashi; Hiroshi (Fuji, JP)
Assignee: Asahi Kasei Kogyo Kabushiki Kaisha (Osaka, JP) Dainippon Pharmaceutical Co., Ltd. (Osaka, JP)
Application Number:06/477,866
Patent Claims:see list of patent claims

Details for Patent 4,447,355

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 10/21/1942 ⤷  Try a Trial 2002-04-07
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 03/03/1954 ⤷  Try a Trial 2002-04-07
Csl Behring Ag ALBURX albumin (human) Injection 102366 07/23/1976 ⤷  Try a Trial 2002-04-07
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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