Patent: 4,447,355

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Summary for Patent: 4,447,355

Title:	Method for stabilizing a tumor necrosis factor and a stable aqueous solution or powder containing the same
Abstract:	A method for stabilizing a Tumor Necrosis Factor (TNF), which comprises adding at least one member selected from the group consisting of an albumin, a gelatin, a globulin, a protamine and a salt of protamine to an aqueous solution or powder containing TNF, and a stable aqueous solution or powder which contains TNF and an effective amount of such a protein. The aqueous solution or powder containing TNF can be stored for a prolonged period of time without losing its activity, and is stable on freezing, thawing, lyophilization or the like.
Inventor(s):	Sakamoto; Hajimu (Fuji, JP), Kiyota; Takao (Fuji, JP), Hayashi; Hiroshi (Fuji, JP)
Assignee:	Asahi Kasei Kogyo Kabushiki Kaisha (Osaka, JP) Dainippon Pharmaceutical Co., Ltd. (Osaka, JP)
Application Number:	06/477,866
Patent Claims:	see list of patent claims

Details for Patent 4,447,355

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2002-04-07
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2002-04-07
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2002-04-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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