Last Updated: August 25, 2026

Patent: 11,634,473

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Summary for Patent: 11,634,473

Title:	Method and device for fast dissolution of solid protein composition
Abstract:	Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.
Inventor(s):	Erez Ilan, Kfir Regev, Dana Leitman, Israel Nur, Moti Meron, John Goodman
Assignee:	Omrix Biopharmaceuticals Ltd , Ethicon Inc
Application Number:	US16/814,088
Patent Claims:	see list of patent claims

Details for Patent 11,634,473

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Omrix Biopharmaceuticals Ltd	CROSSEAL, EVICEL	fibrin sealant (human)	Spray	125010	March 21, 2003	11,634,473	2040-03-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,634,473

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2013098805	⤷ Start Trial
United States of America	2020262892	⤷ Start Trial
United States of America	2013312868	⤷ Start Trial
United States of America	10618950	⤷ Start Trial
Russian Federation	2605710	⤷ Start Trial
Russian Federation	2014131276	⤷ Start Trial
Mexico	351980	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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