Patent: 11,078,296
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Summary for Patent: 11,078,296
| Title: | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| Abstract: | Provided are heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the Cand/or Cdomains, amino acid modifications in the Vand/or Vdomains or a combination thereof. The modified amino acid residues are part of the interface between the light chain and heavy chain and are modified in order to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a mammalian cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer preferentially pairs with the second light chain rather than first. |
| Inventor(s): | Corper Adam Louis, Urosev Dunja, Tom-Yew Stacey A. L., Bleile Dustin Weyland Blue, Spreter Von Kreudenstein Thomas, Dixit Surjit, Lario Paula Irene, Sanches Mario |
| Assignee: | ZYMEWORKS INC. |
| Application Number: | US15896170 |
| Patent Claims: | see list of patent claims |
| Patent landscape, scope, and claims summary: |
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Details for Patent 11,078,296
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Octapharma Pharmazeutika Produktionsges.m.b.h. | CUTAQUIG | immune globulin subcutaneous (human)-hipp | Solution | 125668 | December 12, 2018 | ⤷ Start Trial | 2038-02-14 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
