Last Updated: August 14, 2026

Claims for Patent: 11,078,296

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Summary for Patent: 11,078,296

Title:	Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
Abstract:	Provided are heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the Cand/or Cdomains, amino acid modifications in the Vand/or Vdomains or a combination thereof. The modified amino acid residues are part of the interface between the light chain and heavy chain and are modified in order to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a mammalian cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer preferentially pairs with the second light chain rather than first.
Inventor(s):	Corper Adam Louis, Urosev Dunja, Tom-Yew Stacey A. L., Bleile Dustin Weyland Blue, Spreter Von Kreudenstein Thomas, Dixit Surjit, Lario Paula Irene, Sanches Mario
Assignee:	ZYMEWORKS INC.
Application Number:	US15896170
Patent Claims:

Details for Patent 11,078,296

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Octapharma Pharmazeutika Produktionsges.m.b.h.	CUTAQUIG	immune globulin subcutaneous (human)-hipp	Solution	125668	December 12, 2018	11,078,296	2038-02-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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