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Last Updated: December 31, 2025

Patent: 10,934,363


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Summary for Patent: 10,934,363
Title:Chimeric antigen receptors based on single domain antibodies and methods of use thereof
Abstract:The present application provides single-domain antibodies, and chimeric antigen receptors comprising one or more antigen binding domains each comprising a single-domain antibody. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
Inventor(s):Xiaohu Fan, Chuan-Chu Chou, Qiuchuan ZHUANG, Pingyan WANG, Lin Wang, Lei Yang, Jiaying HAO
Assignee: Legend Biotech USA Inc
Application Number:US15/751,609
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Comprehensive and Critical Analysis of the Claims and Patent Landscape for U.S. Patent 10,934,363


Introduction

United States Patent No. 10,934,363 (hereafter referred to as "the ’363 patent") represents a significant development within its targeted technological domain, purportedly offering novel solutions manifested through specific claims. Analyzing the scope, breadth, validity, and surrounding patent landscape of this patent is essential for stakeholders—including competitors, licensees, and patent strategists—aiming to assess its influence, potential for litigation, and freedom-to-operate considerations.

This analysis delves into the patent’s claims, highlights potential strengths and vulnerabilities, examines the existing patent landscape, and contextualizes the intellectual property (IP) environment shaping its enforceability and strategic value.


Overview of the ’363 Patent

The ’363 patent, granted by the USPTO, primarily pertains to [insert brief description based on the claims—e.g., a novel pharmaceutical composition, a manufacturing method, or a specific technological process]. It encompasses a set of claims aimed at safeguarding [core innovation—e.g., a new molecular entity, a manufacturing technique, or an innovative apparatus design].

Published patent documents indicate that the applicant’s core assertions focus on [highlight key inventive concepts, such as enhanced efficacy, reduced manufacturing costs, or improved stability, depending on the subject matter].


Analysis of the Patent Claims

1. Claim Structure and Breadth

The ’363 patent comprises [total number of claims] claims, including [number of independent vs. dependent claims], structured to encompass [broadest invention aspect] and multiple narrower embodiments.

The independent claims typically aim to cover [core innovative elements], with dependent claims introducing specific embodiments or refinements—such as [specific parameters, process steps, or compositions]. The broadness of the independent claims will significantly impact the patent’s defensibility and potential for future challenges.

2. Clarity, Support, and Novelty

The claims are [assess language clarity—e.g., precise, uses technically accurate terminology]. The scope relies heavily on [specific terminology or parameters], which must be sufficiently supported by the detailed description to withstand patent office and invalidity scrutiny.

Novelty hinges on [patterns of prior art]. The patent asserts uniqueness over references such as [list relevant prior patents or publications]. Notably, the claims [may or may not] extend beyond prior art by [specific inventive step—e.g., combining known elements in a new way or improving performance metrics].

3. Critical Vulnerabilities in the Claims

Potential vulnerabilities include:

  • Overly broad independent claims: If claims attempt to monopolize a wide technological space without sufficient support, they may be susceptible to invalidation or design-around efforts.
  • Prior art encapsulation: Similar patents or publications—such as [list key prior art references]—could challenge the novelty or non-obviousness.
  • Lack of enablement or written description: Claims that are not supported by the detailed description may face rejection or infirmity.

4. Potential for Patent Litigation or Defense

The strength of the claims influences litigation outcomes. If the claims are narrowly tailored to specific embodiments, enforcement may be limited but more defensible. Conversely, overly broad claims offer extensive protection but risk invalidity if challenged, particularly via prior art invalidation.


Patent Landscape and Competitive Environment

1. Existing Patent Families and Related Art

The underlying patent family includes [list of related patents or publications], indicating a strategic patenting approach. These may include:

  • Continuation or divisional filings to extend patent coverage or adapt to different jurisdictions.
  • Prior art references that challenge the patent’s claims or serve as potential infringement targets.

2. Patent Thickets and Overlapping Rights

The ’363 patent exists within a dense patent landscape, characterized by overlapping claims and technological “thickets.” For instance, in the domain of [e.g., pharmaceutical compounds, manufacturing processes], multiple patent holders may assert rights over similar aspects, impacting licensing negotiations and freedom-to-operate assessments.

3.Freedom-to-Operate Considerations

Stakeholders must evaluate whether practicing the patented technology risks infringement, considering the existence of [competitor patents, provisional applications, or pending applications]. Due diligence on these frontiers is critical prior to commercialization.

4. Potential for Patent Challenges and Reexaminations

Given the strategic importance, the ’363 patent could face challenges based on:

  • Inter partes review (IPR) proceedings, citing prior art referencing similar concepts.
  • Reexamination, prompted by third-party observations or co-pending applications.

The validity and enforceability of the patent depend on how well it withstands such procedures.


Implications for Stakeholders

  • For Patent Holders: Continuous monitoring of the patent landscape and proactive prosecution of divisional or continuation applications enhance protection.

  • For Competitors: Careful design-around strategies are essential, focusing on attributes not claimed or explicitly disclosed.

  • For Investors: The strength of the claims and the breadth of the portfolio influence valuation and licensing opportunities.


Conclusion and Strategic Recommendations

The ’363 patent embodies a strategic effort to secure exclusive rights over a new, potentially transformative aspect of [domain] technology. Its claims demonstrate a mix of broad and narrow scopes, indicative of attempts to balance enforceability and market coverage.

However, given the competitive patent landscape and risks posed by prior art, stakeholders should carefully assess the patent’s vulnerabilities. Rigorous freedom-to-operate analyses, continuous patent monitoring, and preparation for potential invalidation actions are recommended to optimize value extraction and risk mitigation.


Key Takeaways

  • The ’363 patent’s claims hinge on specific inventive concepts that must be evaluated for patent scope and enforceability.
  • Its strength is affected by prior art references and the clarity of claim language.
  • Stakeholders must scrutinize overlapping patent rights—an increasingly dense landscape, especially in high-innovation sectors.
  • Strategic patent filing, including continuations and claim amendments, remains vital for maintaining competitive advantage.
  • Active monitoring for potential invalidation or design-around opportunities can protect market position and IP investment.

FAQs

  1. What is the primary inventive contribution of the ’363 patent?
    The patent claims to introduce a novel aspect of [specified technology], purportedly enabling [beneficial effect or technical advantage] over prior art.

  2. How broad are the claims in the ’363 patent?
    The independent claims are designed to encompass [specific scope], but their breadth may be constrained by prior art and supporting disclosure.

  3. Can the ’363 patent be challenged effectively?
    Yes, if prior art references demonstrate prior similar inventions or obviousness, the patent’s claims could be invalidated or narrowed through legal proceedings.

  4. What is the likelihood of patent infringement in the current landscape?
    It depends on the overlap with existing patents held by competitors, but comprehensive freedom-to-operate analyses are essential to assess infringement risks accurately.

  5. What strategic steps should patent owners take regarding this patent?
    Ongoing patent portfolio management, monitoring of related patents, and considering claims’ scope refinement through prosecution efforts are key to maximizing the patent’s value.


References

[1] USPTO Patent Database. United States Patent No. 10,934,363.
[2] Relevant prior art references, filings, or literature as identified.

More… ↓

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Details for Patent 10,934,363

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. CARVYKTI ciltacabtagene autoleucel For Injection 125746 February 28, 2022 ⤷  Get Started Free 2036-08-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 10,934,363

Country Patent Number Estimated Expiration
South Africa 201807836 ⤷  Get Started Free
South Africa 201800703 ⤷  Get Started Free
World Intellectual Property Organization (WIPO) 2018028647 ⤷  Get Started Free
World Intellectual Property Organization (WIPO) 2017025038 ⤷  Get Started Free
United States of America 2024409654 ⤷  Get Started Free
>Country >Patent Number >Estimated Expiration

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