Patent: 10,786,577
✉ Email this page to a colleague
Summary for Patent: 10,786,577
| Title: | Pharmaceutical composition comprising glutatione disulfide and glutathione disulfide S-oxide |
| Abstract: | Pharmaceutical composition comprising glutathione disulphide or pharmaceutically acceptable organic or inorganic salt thereof and glutathione disulfide S-oxide of the following structure: ##STR00001## or pharmaceutically acceptable organic or inorganic salt thereof for eliminating dose-related toxicity and enhancing the therapeutic activity of a pharmacologically active compound in the treatment of infectious and non-infectious diseases is provided. Typically, the composition comprises glutathione disulfide S-oxide in an amount of 0.01-10% by weight of the total composition, and additionally a metal (Me) in the form of coordination compound(s) containing Me-S-glutathione bond, said metal is selected from the platinum group, typically it is platinum. The amount of d-metal coordination compound administered to a patient can be 10.sup.-3 to 10.sup.-15 mol/kg of body weight. The composition can be used in combination with pharmacologically active compound, which is an anticoagulant, factor Xa inhibitor, antimicrobial or antiviral agents to increase their therapeutic activity and eliminate dose-related toxicity. |
| Inventor(s): | Balazovskij; Mark Borisovich (St. Petersburg, RU), Antonov; Viktor Georgievich (St. Petersburg, RU), Ignatenko; Oleg Aleksandrovich (St. Petersburg, RU) |
| Assignee: | OBSCHESTVO S ORGANICHENNOY OTVETSTVENNOSTJU \"IVA FARM\" (St. Petersburg, RU) |
| Application Number: | 16/603,042 |
| Patent Claims: | see list of patent claims |
Details for Patent 10,786,577
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Bavarian Nordic A/s | RABAVERT | rabies vaccine | For Injection | 103334 | October 20, 1997 | 10,786,577 | 2038-07-17 |
| Sanofi Pasteur Sa | IMOVAX RABIES | rabies vaccine | For Injection | 103931 | February 04, 2000 | 10,786,577 | 2038-07-17 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
