Last Updated: June 22, 2026

Patent: 10,744,139

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Summary for Patent: 10,744,139

Title:	Inhibitors of fibroblast growth factor receptor and use thereof
Abstract:	Provided are an irreversible inhibitor of a fibroblast growth factor receptor (FGFR) as indicated by formula I, a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical preparation, a pharmaceutical composition and an application thereof. R1, R2, R3, R4, ring A, Ar, ring B and warhead are as defined in the specification. The compound has high-efficiency and high-selectivity inhibition of a fibroblast growth factor receptor and can be applied to treatment of abnormal FGF/FGFR-mediated diseases, in particular the treatment of cancers.
Inventor(s):	Frank Wu
Assignee:	Transthera Sciences Nanjing Inc
Application Number:	US16/328,817
Patent Claims:	see list of patent claims

Details for Patent 10,744,139

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	August 27, 2009	⤷ Start Trial	2037-08-10
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	June 15, 2011	⤷ Start Trial	2037-08-10
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	July 13, 2011	⤷ Start Trial	2037-08-10
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	March 25, 2014	⤷ Start Trial	2037-08-10
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	October 27, 2023	⤷ Start Trial	2037-08-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,744,139

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Country	Patent Number	Estimated Expiration
Australia	2017317864	⤷ Start Trial
China	107793395	⤷ Start Trial
European Patent Office	3508482	⤷ Start Trial
Spain	2859637	⤷ Start Trial
Japan	2019529374	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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