Last Updated: September 24, 2026

Patent: 10,646,554

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Summary for Patent: 10,646,554

Title:	Methods and compositions for CNS delivery of arylsulfatase A
Abstract:	The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.
Inventor(s):	Nazila Salamat-Miller, Katherine Taylor, Paul Campolieto, Zahra Shahrokh, Jing Pan, Lawrence Charnas, Teresa Leah Wright, Pericles Calias
Assignee:	Takeda Pharmaceutical Co Ltd
Application Number:	US15/684,568
Patent Claims:	see list of patent claims

Details for Patent 10,646,554

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	VECTIBIX	panitumumab	Injection	125147	27-Sep-06	⤷ Start Trial	2037-08-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,646,554

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Country	Patent Number	Estimated Expiration
Argentina	081677	⤷ Start Trial
Argentina	081678	⤷ Start Trial
Argentina	081679	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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