Last Updated: May 31, 2026

Patent: 10,626,463

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Summary for Patent: 10,626,463

Title:	Biomarker associated with risk of melanoma reoccurrence
Abstract:	The present invention provides a method of predicting the risk of reoccurrence of melanoma in a patient from whom melanoma tissue was previously removed which comprises the following: a. obtaining a RNA-containing sample of the previously removed melanoma tissue containing RNA from the patient; b. treating the sample to determine from the RNA contained in the sample the level of expression of a plurality of preselected genes; and c. comparing the level of expression of each gene of the plurality of pre-selected genes to a predetermined reference level of expression for each such gene; wherein a higher level of expression of the plurality of pre-selected genes in the sample as compared with the predetermined reference level of expression of such genes indicates that the patient has a reduced risk of reoccurrence of melanoma.
Inventor(s):	Saenger; Yvonne (New York, NY), Sivendran; Shanthi (Gettysburg, PA), Chang; Rui (New York, NY), Difeo; Analisa (Port Washington, NY)
Assignee:	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, NY)
Application Number:	14/419,409
Patent Claims:	see list of patent claims

Details for Patent 10,626,463

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	IMLYGIC	talimogene laherparepvec	For Injection	125518	October 27, 2015	10,626,463	2033-08-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,626,463

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2014022826	⤷ Start Trial
United States of America	2015218649	⤷ Start Trial
Canada	2918608	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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