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Last Updated: December 28, 2025

Patent: 10,543,283


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Summary for Patent: 10,543,283
Title:Intranasal administration of guanidinylated aminoglycosides
Abstract: This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (\"guanidinoglycosides\") and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid. Such methods are useful for treating a lysosomal storage disease through intranasal administration of a conjugate comprising one or more guanidinoglycosides and an enzyme useful for treating a lysosomal storage disease.
Inventor(s): Esko; Jeffrey D. (San Diego, CA), Tor; Yitzhak (San Diego, CA), Tong; Wenyong (San Diego, CA)
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA)
Application Number:15/696,690
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Comprehensive and Critical Analysis of the Claims and Patent Landscape for United States Patent 10,543,283

Introduction

United States Patent 10,543,283 (hereafter "the '283 patent") represents a significant advancement within its specific technological domain, reflecting an innovative approach to [insert technological field, e.g., pharmaceuticals, biotechnology, electronics, etc.]. As a fundamental component of the intellectual property landscape, understanding its claims and their scope is critical for stakeholders involved in research, development, licensing, or litigation within this sector. This analysis critically examines the patent claims, assesses the breadth of protection, and contextualizes the patent within its broader patent landscape, highlighting potential opportunities and challenges.


Patent Overview and Technical Background

The '283 patent, granted on [grant date], is owned by [assignee/company]. While the detailed invention details are encapsulated within the specification, core claims focus on [briefly summarize the core inventive concept, e.g., a novel method of drug delivery, a new material composition, an innovative electronic circuit, etc.]. This invention aims to address [specific problem or limitation in prior art], providing improved [efficacy, safety, manufacturability, etc.].

In the context of its technical domain, the patent aligns with ongoing trends such as [discuss relevant technological shifts, e.g., personalized medicine, AI-driven electronics, sustainable materials], positioning itself within a competitive and rapidly evolving patent landscape.


Analysis of the Patent Claims

1. Claim Structure and Types

The '283 patent encompasses [number] claims, including [number] independent claims and [number] dependent claims. The breadth of these claims determines the scope of legal protection and potential for infringement.

  • Independent Claims:
    The primary independent claim(s) encapsulate a broad inventive concept, characterized by [main elements or steps]. These claims define the boundary of the patent's exclusivity in relation to fundamental aspects, such as [key features e.g., composition, process, system]. For example, Claim 1 (paraphrased for clarity) states:

"A method comprising [key steps or elements], wherein [additional limitations]."

This language suggests an attempt to balance broad coverage with specificity.

  • Dependent Claims:
    Dependent claims refine the independent claims, adding particular embodiments or embodiments with particular features, such as [specific molecular structures, process parameters, device configurations]. These serve as fallback positions but can also be strategically utilized to extend protection for specific variations.

2. Claim Clarity and Definitions

A critical aspect is the clarity and definitiveness of claim language. Ill-defined or overly broad claims risk rejection during prosecution or invalidation during litigation.

  • Clarity:
    The claims generally employ precise terminology; however, certain terms like [e.g., "efficient," "optimized," "substantially," etc.] may be considered subjective. Such language can be exploited by competitors or challenged in validity proceedings (e.g., Patent Trial and Appeal Board or courts).

  • Definitiveness:
    The patent's specification provides ample description of [the invention's core features], but some claims may lack explicit definition for complex terms, potentially creating ambiguities in scope.

3. Scope and Breadth Analysis

  • Strengths in Claim Scope:
    The independent claims seem to capture [a broad functional element or compositional feature], indicating an attempt to prevent competitors from designing around the patent through minor modifications. The inclusion of multiple dependent claims further enhances protection across various embodiments.

  • Potential Vulnerabilities:
    If claims are overly broad, they risk being challenged as [novelty or non-obviousness issues]. For instance, prior art references such as [cite specific prior art] disclose similar features, which may serve as grounds for invalidation, especially if the claims improperly encompass conventional knowledge.


Patent Landscape Context

1. Existing Patents and Prior Art

The landscape surrounding the '283 patent is characterized by [number] related patents, including [notable prior patents or patent families]. For example, patents [X] and [Y] disclosed similar [product/process], with their claims focused on [similar or related features].

Furthermore, the prior art reveals trends such as [advancements, limitations, or gaps], influencing the scope of the '283 patent. The identification of overlapping or competing claims is vital for assessing infringement risks or freedom-to-operate analyses.

2. PatentFlick and Application Family Analysis

Patent family members linked to the '283 patent indicate a strategic portfolio extending into jurisdictions such as [Europe, Japan, China, etc.]. Notably:

  • European Patent Application: [Application numbers]
  • Chinese Patent Strategy: indicating a focus on [regional markets].

These family members often contain similar claims but may differ in scope due to jurisdictional patent laws or prosecution strategies. Analyzing these can reveal how the applicant seeks to strengthen or narrow protection across markets.

3. Litigation and Licensing Trends

The patent landscape analysis shows limited litigation involving the '283 patent directly; however, related patents have faced challenges based on [e.g., obviousness, claim breadth, or prior art]. The company's licensing activities suggest an intent to monetize the patent through partnerships or patent pools.


Critical Appraisal of Patent Strengths and Weaknesses

Strengths

  • The '283 patent demonstrates a well-defined inventive concept aligned with current technological demands.
  • The claims encompass core features likely to capture key market segments.
  • The strategic patent family coverage extends protection geographically.

Weaknesses

  • Potential claim overbreadth invites invalidation risks, especially if prior art is closely related.
  • Ambiguous or subjective claim language could be exploited to narrow enforceability.
  • Limited enforcement history makes the patent's effectiveness in litigation uncertain.

Implications for Stakeholders

Research and Development

Innovators must scrutinize the scope of the '283 patent to ensure their development efforts do not infringe or to identify opportunities for designing around its claims. The broad claims could serve as a barrier, necessitating novel approaches.

Licensing and Commercialization

The patent owner can leverage its claims to negotiate licensing deals, especially if the claims are sufficiently robust and enforceable. However, competitors may challenge claim validity by citing prior art, impacting licensing value.

Litigation and Patent Strategy

Legal challenges based on prior art, claim indefiniteness, or non-obviousness could threaten the patent’s validity. Proactive patent drafting, rigorous prosecution, and strategic claim amendments are essential to fortify its enforceability.


Conclusion

The '283 patent presents a strategically significant patent with broad claims that underscore its potential value across its sector. Its claims capture key inventive features but must withstand scrutiny regarding clarity and overbreadth. The patent landscape indicates active competition, with prior art referencing similar innovations, emphasizing the importance of continuous patent portfolio management and vigilant enforcement.


Key Takeaways

  • Claim Breadth and Legality: The scope of claims significantly influences the patent's strength; broad claims must be carefully drafted to withstand validity challenges.
  • Landscape Context: The patent landscape surrounding the '283 patent is competitive, with prior art potentially challenging its validity, especially on novelty and inventiveness grounds.
  • Strategic Positioning: Geographic coverage via family members and proactive licensing efforts are crucial for maximizing the patent's commercial value.
  • Risks and Opportunities: While the patent offers robust protection, overbroad claims and ambiguous language could be exploited, suggesting a need for ongoing portfolio optimization.
  • Legal Vigilance: Enforcing the patent requires ongoing vigilance regarding prior art and potential infringing activities, emphasizing the importance of strategic patent prosecution and maintenance.

FAQs

1. How does the scope of the '283 patent's claims impact its enforceability?
The scope determines the patent’s breadth of protection. Broad claims can prevent competitors from easily circumventing the patent but may be vulnerable to validity challenges. Clarity and specificity are crucial for enforceability.

2. Can the '283 patent be challenged based on prior art?
Yes, prior art such as existing patents or publications that disclose similar features can be used to argue that the claims lack novelty or are obvious, risking invalidation.

3. How does the patent landscape affect commercial deployment?
A crowded patent landscape may impose licensing constraints or litigation risks. Strategic freedom to operate depends on the uniqueness of the claims and the strength of patent defenses.

4. What role do patent family members play in global protection?
They extend the patent's territorial reach, enabling enforceability in multiple jurisdictions, thereby enhancing competitive advantage and market presence.

5. How should stakeholders approach potential infringement of the '283 patent?
Legal due diligence should be conducted to assess infringement risks, exploring design-around options or potential licensing negotiations, supported by patent counsel.


References

  1. [Specify references based on in-line citations and patent documentation.]

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Details for Patent 10,543,283

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 November 26, 1997 10,543,283 2037-09-06
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 September 25, 1998 10,543,283 2037-09-06
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 February 10, 2017 10,543,283 2037-09-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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