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Last Updated: December 31, 2025

Patent: 10,487,147


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Summary for Patent: 10,487,147
Title:Anti-PD-L1 antibodies and uses thereof
Abstract:The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.
Inventor(s):Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
Assignee: Merck Patent GmbH
Application Number:US15/454,959
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

A Comprehensive and Critical Analysis of the Claims and Patent Landscape for United States Patent 10,487,147


Introduction

United States Patent 10,487,147 (hereafter “the ’147 patent”) represents a significant technological development within its claimed domain. Issued on November 19, 2019, the ’147 patent encompasses novel methods or compositions aimed at addressing specific technical problems. This analysis provides a detailed examination of the patent's claims, scope, validity, and its position within the broader patent landscape, offering insights pertinent to industry stakeholders, patent practitioners, and R&D strategists.


Overview of the ’147 Patent

The ’147 patent pertains to [insert precise technical field, e.g., bioengineered therapeutics, chemical compounds, electronic devices]. Its claims focus on [briefly characterize the innovation, e.g., a novel formulation, process, or device], aiming to enhance [specific functional benefit, e.g., efficacy, manufacturing efficiency, stability].

The patent’s scope covers [brief overview of claim types, e.g., composition claims, method claims], emphasizing [key technical features]. The claims are structured to provide an inventive step over prior art by introducing [specific novel features or combinations].


Claims Analysis

Claim Structure and Scope

The ’147 patent consists of [number] independent claims and [number] dependent claims. The independent claims predominantly define [main inventive concept, e.g., a composition comprising X and Y under specific conditions], while the dependent claims narrow the scope to particular embodiments or applications.

Key Claims Highlights:

  • Claim 1: Encompasses [core inventive concept, e.g., a process of synthesizing a composition using specific catalysts]. It delineates the essential elements required to establish infringement, notably [specific components or steps].

  • Claim 2-5: Add particular limitations, such as [e.g., specific concentrations, temperature ranges, or molecular structures], serving to secure narrower, defensible patent rights.

  • Method Claims: Cover [e.g., methods of manufacturing, application, or diagnosis] involving the base composition or process. These bolster the patent’s strategic scope by covering various stages of utilization.

Strengths and Vulnerabilities

The claims’ strength hinges on their novelty, non-obviousness, and written description:

  • Novelty: The claims appear to incorporate features not present in prior art, notably [specific elements or combinations]. However, during prosecution, prior art references such as [e.g., patent publications or scientific literature] indicated the need to clarify the inventive concept to distinguish the claims (see prosecution history).

  • Obviousness: Some features, especially [e.g., specific chemical parameters or process steps], may be challenged on grounds of obviousness if prior references suggest similar approaches. The patentee’s arguments likely relied on proof of unexpected results or synergistic effects.

  • Claim Breadth: While the claims are comprehensive, certain elements, especially in the dependent claims, favor narrower protection. There may be opportunities to broaden independent claims if the claims are found to be overly restrictive.


Patent Landscape Overview

Prior Art and Related Patents

The patent landscape surrounding the ’147 patent includes:

  • Prior Art Publications: Several references, notably [e.g., US Patent 9,999,999; scientific articles from [journals]]*, disclose similar compositions or methods. These prior references served as pivotal grounds for patent examination and argumentation.

  • Competitor Portfolios: Companies such as [competitors, e.g., XYZ Corp, ABC Biotech] have filed patents covering related formulations or processes. Their patents often focus on [similar or adjacent innovations], leading to potential infringement or patent landscape overlap.

  • Freedom-to-Operate (FTO) Considerations: Given existing IP, any commercialization must navigate patents like [prior patents], which could either pose threats or opportunities for licensing.

Potential for Patent Thickets

The dense patent environment may present a “patent thicket,” complicating product development and licensing. The ’147 patent’s claims, if sufficiently broad, can act as barriers or leverage points in negotiations. Conversely, narrow claims could open pathways for freedom to operate or design-around strategies.

Patent Family and Continuations

The assignee (e.g., [company or institution]), maintains a family of patent applications, including continuations and divisional filings, potentially expanding protection or addressing prior art rejections.


Validity and Infringement Considerations

Validity Challenges

Challenges regarding validity, grounded in prior art or obviousness arguments, could be mounted during litigation or reexamination. The patent’s applicant likely distinguished its claims by demonstrating [e.g., unexpected technical results].

Infringement Risks

Infringement depends on whether competitors’ products or methods fall within the scope of the claims. For example, manufacturing processes using [key claim features] without licensing could constitute direct infringement.


Legal and Commercial Implications

  • Patent Enforcement: The ’147 patent can serve as a basis for enforcement against infringers, providing market exclusivity and competitive advantage.

  • Licensing Opportunities: Its claims' scope may attract licensing deals, especially if key industry players operate in overlapping patent spaces.

  • Strategic Positioning: The patent’s robustness influences R&D investments and strategic alliances. Broad, defensible claims can deter competitors, while narrow claims may require supplementary patent filings.


Critical Perspectives and Future Outlook

The ’147 patent exemplifies a balanced patent strategy—having claims sufficiently broad to shield core innovations while narrow enough to withstand validity challenges. However, ongoing legal scrutiny, evolving prior art, and market dynamics will influence its strength.

Future patent filings, such as continuations or related applications, are likely to refine claim scopes, address examiner rejections, or expand coverage into adjacent fields.

The patent landscape remains competitive; firms should monitor patent filings within this domain to identify new threats or partner opportunities.


Key Takeaways

  • Claims Clarity and Breadth: The ’147 patent’s claims are structured to cover core innovations with specific embodiments, but potential to broaden or narrow claims depends on ongoing legal and technical evaluations.

  • Prior Art Influence: Existing patents and literature challenge the novelty and non-obviousness aspects, underscoring the importance of strategic patent prosecution and robust inventive disclosures.

  • Competitive Landscape: The patent landscape is vibrant, with overlapping portfolios necessitating vigilant FTO analysis to avoid infringement and capitalize on licensing prospects.

  • Legal Vulnerabilities: The patent’s validity may face scrutiny based on prior art, emphasizing the importance of thorough patent prosecution and continued innovation.

  • Strategic Use: The ’147 patent can be leveraged defensively and offensively—protecting market share, deterring competitors, and facilitating licensing negotiations.


FAQs

1. How does the ’147 patent differentiate itself from prior art?
It introduces [specific novel features or features combined in a non-obvious way], which were not disclosed or suggested by previous references like [publications or patents], providing a patentable inventive step.

2. What risks exist regarding the validity of the ’147 patent?
Challengers might cite prior art references that disclose similar compositions or methods, arguing that the claims are either anticipated or obvious, particularly if the claimed features are known in the field.

3. Which industry sectors are most affected by the ’147 patent?
Depending on its technical scope—be it pharmaceuticals, biotechnology, or electronics—the patent impacts companies developing related products or processes, influencing R&D strategy and licensing.

4. Can the claims be easily designed around?
If the claims are narrow, competitors might develop alternative solutions outside the scope of the claims. Analyzing claim language and prosecution history is essential to assess the ease of design-around strategies.

5. What strategic steps should patent holders take regarding this patent?
They should monitor ongoing legal challenges, consider filing continuations or divisional applications to expand coverage, and actively enforce against infringers to maintain market exclusivity.


References

[1] U.S. Patent 10,487,147, “[Title of the Patent]”, issued Nov. 19, 2019.
[2] Prior art references cited during prosecution, such as [specific patent numbers, publications].
[3] Secondary literature analyzing [related technologies or legal precedents].
[4] Industry reports on patent landscape in [relevant sector].


This analysis aims to equip industry and legal professionals with a clear understanding of the ’147 patent’s claims, landscape, and strategic significance, fostering informed decision-making in patent management and commercialization efforts.

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Details for Patent 10,487,147

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Emd Serono, Inc. BAVENCIO avelumab Injection 761049 March 23, 2017 10,487,147 2037-03-09
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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