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Last Updated: October 1, 2020

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Patent: 10,407,673

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Summary for Patent: 10,407,673
Title:Methods for glycoprotein remodeling using endoglycosidase mutants
Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
Inventor(s): Lin; Nan-Horng (Vernon Hills, IL), Huang; Lin-Ya (New Taipei, TW), Shivatare; Sachin S (Taipei, TW), Chen; Li-Tzu (Taipei, TW), Wong; Chi-Huey (Taipei, TW), Wu; Chung-Yi (New Taipei, TW), Cheng; Ting (Keelung, TW)
Assignee: CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW)
Application Number:16/011,622
Patent Claims:see list of patent claims

Details for Patent 10,407,673

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 002 2017-06-22   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX Orphan search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 001 2017-06-22   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX Orphan search
Wyeth Pharms Inc MYLOTARG gemtuzumab ozogamicin VIAL;SINGLE-DOSE 761060 001 2018-04-09   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX Orphan search
Genentech Inc OCREVUS ocrelizumab INJECTABLE;INJECTION 761053 001 2017-03-28   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX search
Glaxosmithkline Llc BENLYSTA belimumab INJECTABLE;INJECTION 761043 001 2017-07-20   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX search
Biogen ZINBRYTA daclizumab INJECTABLE;INJECTION 761029 001 2017-05-26   Start Trial CHO Pharma Inc. (Taipei, TW) Academia Sinica (Taipei, TW) 2036-08-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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