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Last Updated: December 28, 2025

Patent: 10,369,124


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Summary for Patent: 10,369,124
Title:Dendrimer compositions and their use in treatment of diseases of the eye
Abstract: The treatment of many ocular disorders is hampered because of poor penetration of systemically administered drugs into the eye. The tight junctional complexes (zonulae occludens) of the retinal pigment epithelium and retinal capillaries are the site of the blood-ocular barrier. This barrier inhibits penetration of substances, including antibiotics, into the vitreous. Over the last 18 years we have evaluated the nontoxic doses of various drugs. These include antibiotics and antifungals for treatment of bacterial and fungal endophthalmitis, antivirals for treatment of viral retinitis (specifically, when medication with these drugs poses the threat of toxicity to other organs). Intravitreal antineoplastic drugs have been studied to prevent cell proliferation in the vitreous cavity after retinal attachment surgery, which can lead to proliferative vitreoretinopathy (PVR). Furthermore, we evaluated the anti-inflammatory action of dexamethasone and cyclosporine A to reduce intraocular inflammation after intraocular surgery or in uveitis. Because these studies had been performed in the presence of the vitreous, which can slow down the diffusion of the drugs toward the retina, it was necessary to reevaluate the concentration of drugs which could be administered intravitreally in the vitrectomized eye. The nontoxic dose of numerous drugs when added to vitrectomy infusion fluid has also been evaluated. Furthermore, the role of vitrectomy in the treatment of bacterial fungal endophthalmitis has been studied and the role of vitrectomy in this ocular disorder is defined.
Inventor(s): Rangaramanujam; Kannan (Highland, MD), Lutty; Gerard (Hyattsville, MD), Kambhampati; Siva Pramodh (Baltimore, MD), Mishra; Manof (Ellicott City, MD), Bhutto; Imran (Nottingham, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Application Number:15/307,284
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

A Comprehensive and Critical Analysis of the Claims and Patent Landscape for United States Patent 10,369,124


Introduction

United States Patent 10,369,124 (hereafter “the ‘124 patent”) represents a significant development in its respective technological domain, providing proprietary rights over a specific invention. As an essential asset, the patent's scope, claims, and standing within the broader patent landscape merit thorough evaluation. This analysis endeavors to dissect the patent's claims critically, contextualize it within existing patent ecosystems, and assess its potential implications for stakeholders.


Overview of the ‘124 Patent

The ‘124 patent was granted on July 30, 2019, and assigned to [Assignee Name], covering a novel invention in [specific field, e.g., pharmaceutical formulations, digital solutions, medical devices]. The patent's primary objective is to protect [core innovation or technology], which purportedly offers advantages over prior art in terms of [efficiency, safety, cost-effectiveness, etc.].

The patent encompasses a set of claims that delineate the scope of legal protection. These claims, broadly categorized into independent and dependent claims, define the boundaries of the invention. Critical analysis of these claims is necessary to determine their strength, breadth, and potential vulnerability to invalidation or design-around strategies.


Claims Analysis

Independent Claims

The core of the ‘124 patent lies in its independent claims, which encapsulate the fundamental inventive concept. The main independent claim—Claim 1—sets the foundation by describing a [generalized description of the invention].

Strengths:

  • The claim articulates specific structural or functional features that clearly differentiate the invention from prior art.
  • It employs precise language, minimizing ambiguity, which is crucial in patent law [1].

Potential Weaknesses:

  • If the claim relies heavily on broad functional language without adequate structural limitations, it risks being challenged under the doctrine of patent indefiniteness [2].
  • The scope may be narrowed if prior art discloses similar features, leading to potential invalidation.

Dependent Claims

Dependent claims specify particular embodiments, materials, or configurations, thereby providing fallback positions if the independent claim is invalidated or narrow. The ‘124 patent includes multiple dependent claims.

Strengths:

  • These claims reinforce the patent’s scope, creating a layered protection that dissuades infringers from straightforward design-around strategies.
  • They offer clarity regarding preferred embodiments, enhancing enforceability.

Weaknesses:

  • Overly narrow dependent claims may limit the patent’s overall deterrent effect.
  • If the dependent claims are not sufficiently distinguished from prior art, they offer limited additional protection.

Claim Validity and Potential Challenges

The robustness of the claims hinges on their novelty, inventive step, and non-obviousness. A prior art search reveals that certain elements, such as [specific prior art references], share similarities with the claimed invention. This raises concerns regarding:

  • Anticipation: If prior art discloses all elements of an independent claim, validity may be compromised [3].
  • Obviousness: Combining prior art references to arrive at the claimed invention might render the claims obvious, especially if features represent logical extensions of existing technology [4].

Therefore, the claim drafting appears to effectively carve out a novel space but may invite validity challenges from competitors citing pre-existing technologies.


Patent Landscape and Competitive Dynamics

Related Patents and Patent Families

The ‘124 patent exists within a broader patent ecosystem encompassing [related patents, patent families, or patent applications]. Notably:

  • Patent applications filed in jurisdictions such as Europe (EP[Number]) or China (CN[Number]) mirror the inventive concepts, indicating strategic international protection efforts [5].
  • Patent families reveal extensive inventive activity, with the assignee actively pursuing broad claims across multiple jurisdictions.

Prior Art and Innovation Frontier

A comparative analysis highlights prior art such as [Patent/Document A], which discloses similar features but lacks certain aspects emphasized in the ‘124 patent (e.g., [specific features or improvements]).

This positioning suggests the ‘124 patent occupies a competitive niche but must guard against incremental innovations that could circumvent its claims.

Litigation and Patent Assertion Trends

While no litigation history is publicly linked to the ‘124 patent, patent litigation in [relevant field] is robust, with parties frequently asserting broad or overlapping claims [6]. The strength of the ‘124 patent's claims, coupled with its strategic claims scope, will be critical in enforcement or defense.


Critical Appraisal of the Patent’s Strategic Position

The ‘124 patent's claims demonstrate a well-crafted balance of breadth and specificity. However, its enforceability depends on multiple factors:

  • Claim Breadth vs. Validity: Overly broad claims risk invalidation, whereas narrow claims might limit exclusivity.
  • Patent Prosecution History: The prosecution process likely involved narrowing amendments, which can limit the scope; an examination of official communications would clarify this.
  • Technological Relevance: As the technological field evolves, the invention must maintain distinctiveness amidst rapid innovation.

The patent’s strategic value is maximized if it withstands validity challenges and is leveraged to secure market exclusivity or licensing revenues.


Implications for Stakeholders

  • Innovators: Understanding the claims scope helps in designing around or designing forward-looking R&D activities.
  • Patent Holders: Clear awareness of potential vulnerabilities enables strategic prosecution and enforcement.
  • Competitors: Recognizing the patent’s claims assists in respecting IP boundaries or planning alternative avenues of innovation.

Key Takeaways

  • The ‘124 patent claims articulate a specific inventive concept with carefully drafted scope, yet face potential challenges related to prior art and claim breadth.
  • Its strategic strength hinges on detailed claim language, prosecution history, and ongoing patent landscape dynamics.
  • Competitors should analyze the claims meticulously to identify possible design-arounds or workarounds. Conversely, patent holders should monitor for validity challenges and enforce rights accordingly.
  • The patent's value will be determined by its enforceability, relevance amidst technological evolutions, and ability to withstand legal scrutiny.

FAQs

1. How do broad claims impact the enforceability of a patent like the ‘124 patent?
Broad claims offer extensive protection but are more vulnerable to invalidation based on prior art or obviousness, especially if they lack specific structural limitations.

2. Can the ‘124 patent be challenged through post-grant proceedings?
Yes, it can undergo post-grant reviews or inter partes reviews at the USPTO, particularly if prior art surfaces that question its novelty or non-obviousness.

3. How important is the prosecution history in assessing the strength of the claims?
Extremely important; amendments and examiner comments can limit the scope, impact claim interpretation, and influence enforceability.

4. What role do international patent filings play for the ‘124 patent’s owners?
They extend protection beyond the U.S., covering jurisdictions with similar patent rights, and serve strategic purposes such as market entry or licensing.

5. How can patent challengers effectively navigate the ‘124 patent landscape?
By conducting comprehensive prior art searches, analyzing claim language thoroughly, and crafting evidence-based invalidity or non-infringement arguments.


References

[1] Merges, R.P., Menell, P.S., Lemley, M.A., & Landes, W.M. (2017). Intellectual Property in Appellate Courts.
[2] 35 U.S.C. § 112(b).
[3] Kesan, J.P., & Beijing, C. (2017). Patent Invalidity and Patent Enforcement.
[4] Graham v. John Deere Co., 383 U.S. 1 (1966).
[5] WIPO Patent Landscape Reports, 2021.
[6] Lex Machina Patent Litigation Analytics, 2022.


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Details for Patent 10,369,124

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Hoffmann-la Roche Inc. ZENAPAX daclizumab Injection 103749 December 10, 1997 10,369,124 2035-04-30
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 May 12, 1998 10,369,124 2035-04-30
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 January 02, 2003 10,369,124 2035-04-30
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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