Method, kit, plasmid and composition for inducing an immune response to dengue virus, on the basis of DNA and chimeric virus vaccines
Abstract:
The present invention relates to a method for inducing an immune response to the dengue virus, on the basis of DNA and 17D chimeric virus vaccines in combined or co-administered immunisation. The scope of the present invention also includes DNA vaccines against the four serotypes of the dengue virus, produced by forming, from each viral serotype of the dengue virus (DENV1-4), various recombinant plasmids that contain the gene that codes for the E protein, or that contain only the sequence that corresponds to the domain III of this protein. The invention also provides a vaccine composition consisting of (a) DNA vaccines against the four serotypes of the dengue virus; (b) chimeric viruses comprising the modified yellow fever vaccination virus 17D; and (c) a pharmaceutically acceptable carrier, all of which are covered by the scope of the invention.
Inventor(s):
Alves Ada Maria de Barcelos, Azevedo Adriana de Souza, Galler Ricardo, Freire Marcos da Silva
United States Patent 10,357,558 Claims and US Patent Landscape: Validity, Scope, Expiration, and Generic Risk
Executive summary: USPTO Patent 10,357,558 sits in a US landscape where (i) claim scope and enforceability depend on the exact asserted claim text, intrinsic record, and prosecution history; (ii) the patent’s practical value is driven by whether its independent claims cover a still-commercial product form, dosing regimen, method-of-use, or manufacturing step; and (iii) generic or follow-on entry risk typically correlates with the Orange Book status of the relevant FDA application and whether existing Paragraph IV filings or FDA approvals target the protected subject matter. Critical limitation: the request does not include the patent’s claims or even the claim list text. Without the claim set, a complete, accurate claim-by-claim infringement, validity, and freedom-to-operate analysis cannot be produced.
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