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Last Updated: December 30, 2025

Claims for Patent: 10,357,558


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Summary for Patent: 10,357,558
Title:Method, kit, plasmid and composition for inducing an immune response to dengue virus, on the basis of DNA and chimeric virus vaccines
Abstract:The present invention relates to a method for inducing an immune response to the dengue virus, on the basis of DNA and 17D chimeric virus vaccines in combined or co-administered immunisation. The scope of the present invention also includes DNA vaccines against the four serotypes of the dengue virus, produced by forming, from each viral serotype of the dengue virus (DENV1-4), various recombinant plasmids that contain the gene that codes for the E protein, or that contain only the sequence that corresponds to the domain III of this protein. The invention also provides a vaccine composition consisting of (a) DNA vaccines against the four serotypes of the dengue virus; (b) chimeric viruses comprising the modified yellow fever vaccination virus 17D; and (c) a pharmaceutically acceptable carrier, all of which are covered by the scope of the invention.
Inventor(s):Alves Ada Maria de Barcelos, Azevedo Adriana de Souza, Galler Ricardo, Freire Marcos da Silva
Assignee:Fundacao Oswaldo Cruz
Application Number:US13499697
Patent Claims:

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