Last Updated: August 14, 2026

Patent: 10,314,904

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Summary for Patent: 10,314,904

Title:	Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist
Abstract:	The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.
Inventor(s):	Purcell; Lisa (Garnerville, NY), Graham; Neil (Croton-on-Hudson, NY), Murphy; Andrew J. (Croton-on-Hudson, NY), Evans; Robert (Cambridge, MA)
Assignee:	Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:	15/436,032
Patent Claims:	see list of patent claims

Details for Patent 10,314,904

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Regeneron Pharmaceuticals, Inc.	DUPIXENT	dupilumab	Injection	761055	March 28, 2017	10,314,904	2037-02-17
Regeneron Pharmaceuticals, Inc.	DUPIXENT	dupilumab	Injection	761055	October 19, 2018	10,314,904	2037-02-17
Regeneron Pharmaceuticals, Inc.	DUPIXENT	dupilumab	Injection	761055	June 18, 2020	10,314,904	2037-02-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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