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Last Updated: October 26, 2020

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Patent: 10,259,859

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Summary for Patent: 10,259,859
Title:Constructs having a SIRP-.alpha. domain or variant thereof
Abstract: The present disclosure features signal-regulatory protein .alpha. (SIRP-.alpha.) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-.alpha. constructs include a high affinity SIRP-.alpha. D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-.alpha.. The SIRP-.alpha. polypeptides or constructs include a SIRP-.alpha. D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein .alpha. (SIRP-.alpha.) D1 variant and (ii) an antibody.
Inventor(s): Pons; Jaume (San Carlos, CA), Deming; Laura (Palo Alto, CA), Goodman; Corey (Marshall, CA), Sim; Bang Janet (Brisbane, CA), Kauder; Steven Elliot (San Mateo, CA), Wan; Hong (Foster City, CA), Kuo; Tracy Chia-Chien (San Mateo, CA)
Assignee: ALX ONCOLOGY INC. (Burlingame, CA)
Application Number:15/230,186
Patent Claims:see list of patent claims

Details for Patent 10,259,859

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial ALX ONCOLOGY INC. (Burlingame, CA) 2035-08-07 RX search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 002 2017-06-22   Start Trial ALX ONCOLOGY INC. (Burlingame, CA) 2035-08-07 RX Orphan search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 001 2017-06-22   Start Trial ALX ONCOLOGY INC. (Burlingame, CA) 2035-08-07 RX Orphan search
Glaxosmithkline Llc BENLYSTA belimumab INJECTABLE;INJECTION 761043 001 2017-07-20   Start Trial ALX ONCOLOGY INC. (Burlingame, CA) 2035-08-07 RX search
Genentech Inc TECENTRIQ atezolizumab INJECTABLE; INJECTION 761041 001 2016-10-18   Start Trial ALX ONCOLOGY INC. (Burlingame, CA) 2035-08-07 RX search
Janssen Biotech DARZALEX daratumumab INJECTABLE;INJECTION 761036 002 2015-11-16   Start Trial ALX ONCOLOGY INC. (Burlingame, CA) 2035-08-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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