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Last Updated: April 25, 2024

Patent: 10,259,859

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Summary for Patent: 10,259,859

Title:	Constructs having a SIRP-.alpha. domain or variant thereof
Abstract:	The present disclosure features signal-regulatory protein .alpha. (SIRP-.alpha.) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-.alpha. constructs include a high affinity SIRP-.alpha. D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-.alpha.. The SIRP-.alpha. polypeptides or constructs include a SIRP-.alpha. D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein .alpha. (SIRP-.alpha.) D1 variant and (ii) an antibody.
Inventor(s):	Pons; Jaume (San Carlos, CA), Deming; Laura (Palo Alto, CA), Goodman; Corey (Marshall, CA), Sim; Bang Janet (Brisbane, CA), Kauder; Steven Elliot (San Mateo, CA), Wan; Hong (Foster City, CA), Kuo; Tracy Chia-Chien (San Mateo, CA)
Assignee:	ALX ONCOLOGY INC. (Burlingame, CA)
Application Number:	15/230,186
Patent Claims:	see list of patent claims

Details for Patent 10,259,859

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997	⤷ Try a Trial	2035-08-07
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998	⤷ Try a Trial	2035-08-07
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017	⤷ Try a Trial	2035-08-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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