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Last Updated: August 11, 2020

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Patent: 10,253,108

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Summary for Patent: 10,253,108
Title:Mutated antibody of fully humanized HER2 antibody, and encoding gene and use thereof
Abstract: The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 11, SEQ ID NO: 2; or SEQ ID NO: 12, SEQ ID NO: 2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.
Inventor(s): Zhou; Qing (Shanghai, CN), Shu; Mengjun (Shanghai, CN), He; Zhuzi (Shanghai, CN), Lin; Jun (Shanghai, CN)
Assignee: Genor Biopharma Co., Ltd. (Shanghai, CN)
Application Number:15/304,199
Patent Claims:see list of patent claims

Details for Patent 10,253,108

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial Genor Biopharma Co., Ltd. (Shanghai, CN) 2035-01-30 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Genor Biopharma Co., Ltd. (Shanghai, CN) 2035-01-30 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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