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Last Updated: December 2, 2020

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Patent: 10,172,808

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Summary for Patent: 10,172,808
Title:Combinations of mRNAs encoding immune modulating polypeptides and uses thereof
Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36.gamma. (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Inventor(s): Frederick; Joshua (Boston, MA), Bai; Ailin (Newton, MA), Presnyak; Vladimir (Cambridge, MA), Hoge; Stephen (Brookline, MA), Benenato; Kerry (Sudbury, MA), McFadyen; Iain (Arlington, MA), Kumarasinghe; Ellalahewage Sathyajith (Harvard, MA), Hewitt; Susannah (Jamaica Plain, MA)
Assignee: ModernaTX, Inc. (Cambridge, MA)
Application Number:15/995,889
Patent Claims:see list of patent claims

Details for Patent 10,172,808

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Emd Serono Inc BAVENCIO avelumab INJECTABLE;INTRAVENOUS 761078 001 2017-05-09   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX search
Astrazeneca Uk Ltd IMFINZI durvalumab INJECTABLE;INJECTION 761069 001 2017-05-01   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX search
Emd Serono Inc BAVENCIO avelumab INJECTABLE;INJECTION 761049 001 2017-04-25   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX Orphan search
Genentech Inc TECENTRIQ atezolizumab INJECTABLE; INJECTION 761041 001 2016-10-18   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX search
Genentech Inc TECENTRIQ atezolizumab INJECTABLE;INJECTION 761034 001 2017-04-17   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX Orphan search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125554 001 2015-11-23   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX Orphan search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 002 2015-03-04   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,172,808

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2017201325   Start Trial
World Intellectual Property Organization (WIPO) 2017201350   Start Trial
World Intellectual Property Organization (WIPO) 2017201352   Start Trial
United States of America 10285950   Start Trial
United States of America 10322090   Start Trial
United States of America 10322091   Start Trial
United States of America 10335486   Start Trial
>Country >Patent Number >Estimated Expiration

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