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Last Updated: December 15, 2019

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Patent: 10,172,808

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Summary for Patent: 10,172,808
Title:Combinations of mRNAs encoding immune modulating polypeptides and uses thereof
Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36.gamma. (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Inventor(s): Frederick; Joshua (Boston, MA), Bai; Ailin (Newton, MA), Presnyak; Vladimir (Cambridge, MA), Hoge; Stephen (Brookline, MA), Benenato; Kerry (Sudbury, MA), McFadyen; Iain (Arlington, MA), Kumarasinghe; Ellalahewage Sathyajith (Harvard, MA), Hewitt; Susannah (Jamaica Plain, MA)
Assignee: ModernaTX, Inc. (Cambridge, MA)
Application Number:15/995,889
Patent Claims:see list of patent claims

Details for Patent 10,172,808

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Emd Serono Inc BAVENCIO avelumab INJECTABLE;INTRAVENOUS 761078 001 2017-05-09   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX search
Astrazeneca Uk Ltd IMFINZI durvalumab INJECTABLE;INJECTION 761069 001 2017-05-01   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX search
Emd Serono Inc BAVENCIO avelumab INJECTABLE;INJECTION 761049 001 2017-04-25   Start Trial ModernaTX, Inc. (Cambridge, MA) 2036-05-18 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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