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Generated: September 15, 2019

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Patent: 10,168,326

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Summary for Patent: 10,168,326
Title:Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples
Abstract: Herein is reported an enzyme linked immunosorbent assay for the detection of anti-drug antibodies against a drug antibody in a sample comprising a capture drug antibody and a tracer drug antibody, wherein the capture drug antibody and the tracer drug antibody are employed in a concentration of 0.5 .mu.g/ml or more, the sample is incubated simultaneously with the capture drug antibody and the tracer drug antibody for 1 to 24 hours, the capture drug antibody and the tracer drug antibody are derivatized via a single lysine residue, the sample comprises 10% serum, and oligomeric human IgG is added to the sample prior to the incubation with the capture drug antibody and the tracer drug antibody.
Inventor(s): Stubenrauch; Kay-Gunnar (Penzberg, DE), Vogel; Rudolf (Weilheim, DE)
Assignee: F. HOFFMANN-LA ROCHE INC. (Nutley, NJ)
Application Number:15/078,140
Patent Claims:see list of patent claims

Details for Patent 10,168,326

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech ACTEMRA tocilizumab INJECTABLE; INJECTION 125276 001 2010-01-08 ➤ Sign Up F. HOFFMANN-LA ROCHE INC. (Nutley, NJ) 2033-07-04 RX search
Genentech ACTEMRA tocilizumab INJECTABLE; INJECTION 125276 002 2010-01-08 ➤ Sign Up F. HOFFMANN-LA ROCHE INC. (Nutley, NJ) 2033-07-04 RX search
Genentech ACTEMRA tocilizumab INJECTABLE; INJECTION 125276 003 2010-01-08 ➤ Sign Up F. HOFFMANN-LA ROCHE INC. (Nutley, NJ) 2033-07-04 RX search
Genentech ACTEMRA tocilizumab INJECTABLE;INTRAVENOUS, SUBCUTANEOUS 125472 001 2013-10-21 ➤ Sign Up F. HOFFMANN-LA ROCHE INC. (Nutley, NJ) 2033-07-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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