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Last Updated: October 22, 2021

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Patent: 10,168,326

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Summary for Patent: 10,168,326
Title:Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples
Abstract: Herein is reported an enzyme linked immunosorbent assay for the detection of anti-drug antibodies against a drug antibody in a sample comprising a capture drug antibody and a tracer drug antibody, wherein the capture drug antibody and the tracer drug antibody are employed in a concentration of 0.5 .mu.g/ml or more, the sample is incubated simultaneously with the capture drug antibody and the tracer drug antibody for 1 to 24 hours, the capture drug antibody and the tracer drug antibody are derivatized via a single lysine residue, the sample comprises 10% serum, and oligomeric human IgG is added to the sample prior to the incubation with the capture drug antibody and the tracer drug antibody.
Inventor(s): Stubenrauch; Kay-Gunnar (Penzberg, DE), Vogel; Rudolf (Weilheim, DE)
Assignee: F. HOFFMANN-LA ROCHE INC. (Nutley, NJ)
Application Number:15/078,140
Patent Claims:see list of patent claims

Details for Patent 10,168,326

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. ACTEMRA tocilizumab Injection 125276 2010-01-08 ⤷  Free Forever Trial 2033-07-04
Genentech, Inc. ACTEMRA tocilizumab Injection 125472 2013-10-21 ⤷  Free Forever Trial 2033-07-04
Genentech, Inc. ACTEMRA tocilizumab Injection 125472 2018-11-19 ⤷  Free Forever Trial 2033-07-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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