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Last Updated: December 11, 2019

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Patent: 10,086,076

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Summary for Patent: 10,086,076
Title:Interleukin-13 binding proteins
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
Inventor(s): Wu; Chengbin (Shanghai, CN), Dixon; Richard W. (Jefferson, MA), Belk; Jonathan P. (Grantham, NH), Ying; Hua (Holden, MA), Argiriadi; Maria A. (Southborough, MA), Cuff; Carolyn A. (Grafton, MA), Hinton; Paul R. (Sunnyvale, CA), Kumar; Shankar (Pleasanton, CA), Melim; Terry L. (Derry, NH), Chen; Yan (Alameda, CA)
Assignee: AbbVie Inc. (North Chicago, IL)
Application Number:15/457,264
Patent Claims:see list of patent claims

Details for Patent 10,086,076

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech XOLAIR omalizumab VIAL 103976 001 2003-06-20   Start Trial AbbVie Inc. (North Chicago, IL) 2026-09-08 RX search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial AbbVie Inc. (North Chicago, IL) 2026-09-08 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial AbbVie Inc. (North Chicago, IL) 2026-09-08 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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