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Patent: 10,081,657
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Summary for Patent: 10,081,657
| Title: | Biosynthetic proline/alanine random coil polypeptides and their uses |
| Abstract: | The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, in which the biosynthetic random coil polypeptide, the biosynthetic random coil polypeptide segment, or the biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein the amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. The at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or conjugates are described. |
| Inventor(s): | Skerra; Arne (Freising, DE), Binder; Uli (Freising, DE), Schlapschy; Martin (Freising, DE) |
| Assignee: | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) |
| Application Number: | 14/939,626 |
| Patent Claims: | see list of patent claims |
Details for Patent 10,081,657
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Biovitrum Ab | KINERET | anakinra | VIAL; SUBCUTANEOUS | 103950 | 003 | 2001-11-14 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | RX | search | |
| Biovitrum Ab | KINERET | anakinra | VIAL; SUBCUTANEOUS | 103950 | 002 | 2001-11-14 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | RX | search | |
| Biovitrum Ab | KINERET | anakinra | VIAL; SUBCUTANEOUS | 103950 | 001 | 2001-11-14 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | RX | search | |
| Ekr Therap | RETAVASE | reteplase | VIAL | 103786 | 001 | 1998-05-06 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | RX | search | |
| Akorn Inc | HYDASE | hyaluronidase | INJECTABLE;INJECTION | 021716 | 001 | 2005-10-25 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | DISCN | search | |
| Amphastar Pharm | AMPHADASE | hyaluronidase | INJECTABLE;INJECTION | 021665 | 001 | 2005-11-03 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | RX | search | |
| Bausch And Lomb | VITRASE | hyaluronidase | INJECTABLE;INJECTION | 021640 | 002 | 2004-12-21 | Start Trial | TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE) | 2030-05-21 | RX | search | |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 10,081,657
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2011144756 | Start Trial |
| United States of America | 2013072420 | Start Trial |
| United States of America | 2016137698 | Start Trial |
| United States of America | 2018354992 | Start Trial |
| United States of America | 9221882 | Start Trial |
| Turkey | 201815734 | Start Trial |
| Slovenia | 2571510 | Start Trial |
| >Country | >Patent Number | >Estimated Expiration |
