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Patent: 10,081,657

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Summary for Patent: 10,081,657

Title:	Biosynthetic proline/alanine random coil polypeptides and their uses
Abstract:	The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, in which the biosynthetic random coil polypeptide, the biosynthetic random coil polypeptide segment, or the biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein the amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. The at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) constituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or conjugates are described.
Inventor(s):	Skerra; Arne (Freising, DE), Binder; Uli (Freising, DE), Schlapschy; Martin (Freising, DE)
Assignee:	TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE)
Application Number:	14/939,626
Patent Claims:	see list of patent claims

Details for Patent 10,081,657

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Bausch And Lomb	VITRASE	hyaluronidase	INJECTABLE;INJECTION	021640	001	2004-12-21		TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE)	2030-05-21	RX		search
Bausch And Lomb	VITRASE	hyaluronidase	INJECTABLE;INJECTION	021640	002	2004-12-21		TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE)	2030-05-21	RX		search
Amphastar Pharm	AMPHADASE	hyaluronidase	INJECTABLE;INJECTION	021665	001	2005-11-03		TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE)	2030-05-21	RX		search
Akorn Inc	HYDASE	hyaluronidase	INJECTABLE;INJECTION	021716	001	2005-10-25		TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE)	2030-05-21	DISCN		search
Ekr Therap	RETAVASE	reteplase	VIAL	103786	001	1998-05-06		TECHNISCHE UNIVERSITAT MUNCHEN (Munich, DE) XL-PROTEIN GMBH (Freising, DE)	2030-05-21	RX		search

International Patent Family for US Patent 10,081,657

Country	Patent Number	Estimated Expiration
Australia	2011254564
Australia	2014203517
Brazil	112012029577
Canada	2794614
China	102883734