Last Updated: September 29, 2026

Patent: 10,076,547

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Summary for Patent: 10,076,547

Title:	Gene-modified coxsackievirus
Abstract:	A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a mutated genome consisting of the genome of coxsackievirus B3 wild-type (CVB3-WT) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific microRNA (miRNA) is provided. The mutated genome is preferably further inserted with the region encoding GM-CSF in an expressible form.
Inventor(s):	Kenzaburo Tani, Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara
Assignee:	Neoprecision Therapeutics Co Ltd , NPT CO Ltd
Application Number:	US14/785,222
Patent Claims:	see list of patent claims

Details for Patent 10,076,547

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338	2-Feb-10	10,076,547	2034-04-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,076,547

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Country	Patent Number	Estimated Expiration
European Patent Office	2987858	⤷ Start Trial
Japan	6396891	⤷ Start Trial
Japan	WO2014171526	⤷ Start Trial
United States of America	2016143969	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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